摘要
目的探讨胆囊切除术对患者细胞免疫功能的影响。方法在患者胆囊切除当天清晨和术后20h抽取其外周血,用流式细胞术检测CD3+、CD4+和CD8+;用ELISA检测IL-2和IL-4水平。结果患者术后CD3+、CD4+含量增加,CD4+/CD8+比值上升,CD8+含量基本无变化;IL-2水平下降,IL-4水平上升。结论胆囊切除后,患者细胞免疫功能紊乱,Th2反应增强、Th1反应受抑制,可能与术后感染的发生有关。
Objective To discuss the influence of cholecystectomy on cellular immune function. Methods Peripheral venous blood of the patients was withdrawn to detect the percentage of CD3^＋, CD4^＋ and CD8^＋ with flow cytometry and the level of IL-2 and IL-4 with ELISA. Results Compared with those before cholecystectomy, the percentages of CD3^＋, CD4^＋, the ratio of CD4^＋/CD8^＋ and the level of IL-2 increased, but the Ievels of IL-4 decreased significantly（P 〈 0.01 ）. Conclusion Cholecyst ectomy may cause disorder of cellular immune function in the patients, to be more exact, the Th2 action increase while Thl decrease,which might be associated with postoperative infection.
出处
《中国现代医生》
2007年第11Z期28-29,共2页
China Modern Doctor
关键词
胆囊切除术
T细胞亚群
细胞免疫
感染
Cholecystectomy
T lymphocyte subsets
Cellular immune function
Infection
