摘要
目的研究分析类风湿关节炎(RA)患者关节滑膜组织中B7-H1蛋白的表达,旨在探讨其在RA发病中的意义。方法采用免疫组织化学SABC法检测24例RA患者膝关节滑膜组织中B7-H1蛋白的表达,并以骨关节炎患者(OA)和健康人膝关节滑膜组织做对照研究。结果24例RA患者膝关节滑膜组织中21例(87.5%)B7-H1蛋白表达阳性,10例OA患者中3例(30.0%)B7-H1蛋白表达阳性,而6例正常对照组中有1例(16.7%)表达阳性,三者比较差异有显著性(P<0.05)。且B7-H1蛋白在滑膜增生严重的RA患者中表达更高。结论B7-H1在RA患者的膝关节滑膜组织中高表达,可能直接参与了RA的发病过程。
Objective To explore its pathological role in rheumatoid arthritis （RA）, and analyze the expression of B7-H1 in human RA synovium. Methods B7-H1 protein was detected in synovium of 24 RA patients by SABC immunohistochemistry. Synovial tissues from patients with osteoarthritis （OA） and healthy individuals were used as controls. Results The results showed that the B7-H1 in the knee synovial tissues of 21 patients were observed moderately positive in 24 patients with rheumatoid arthritis, compared with 3 cases positive in 10 patients with osteoarthritis,whereas 1 case was observed positive of 10 patients with the normal synovial tissues. The difference among three groups was significant （P 〈 0. 05）. Conclusion B7-H1 is highly expressed in RA, and it may play an important role in the pathogenesis of RA.
出处
《河南科技大学学报（医学版）》
2007年第4期244-246,共3页
Journal of Henan University of Science & Technology:Medical Science
基金
河南省卫生厅科技攻关项目(20050045)
