摘要
[目的]分析唐山地区耐药MTB对二线药物的耐药情况,初步探讨本地广泛耐药结核病(XDR-TB)在MDR-TB中的比例。[方法]收集唐山地区2004.11.01～2005.10.31结核病患者痰标本,进行分离培养和表型分群,并对4种二线药物应用绝对浓度法进行耐药性检测。[结果]在所分离的102株耐药结核分枝杆菌中,对二线药物的耐药顺位依次为OFL>PAS>Cp>K,30%MDR-TB菌株同时耐4种二线药物,1/3的MDR-TB属于XDR-TB。[结论]唐山地区MTB二线药物耐药情况严重,MDR-TB中的XDR-TB比例过高。
[Objective]To analyze the state of drug resistance of MTB to the second-line antituberculosis drugs,and preliminary explore the distribution of extensively drug-resistant tuberculosis in MDR-TB in Tangshan area.[Methods]The sputum samples of patients with TB were cdlected from Nov.1th,2004 to Oct.31th,2005 to conduct isolated wlture and phenotypical classification.The four types of second-line antituberculosis drugs were performed to detect the durg-resistance with the method of the absolute concentration.[Results]Out of the 102 isolating MTB,the drug-resistant MTB to the second-line antituberculosis drugs was by the order as follows：OFL 〉 PAS 〉 Cp 〉 K,as well as 30% of the MDR-TB samples resisted four second-line antituberculosis drugs,and one third of MDR-TB belonged to XDR-TB.[Conclusion]Drug resistance to the second-line antituberculosis drugs is very serious in Tangshan area,and the XDR-TB shows high proportion in the MDR-TB.
出处
《现代预防医学》
CAS
北大核心
2007年第24期4728-4729,共2页
Modern Preventive Medicine
关键词
结核分枝杆菌
二线药物
广泛耐药结核病
Mycobacterium tuberculosis
Second-line drug
Extensively drug-resistant tuberculosis
