摘要
目的:观察加味酸枣仁汤治疗慢性乙型肝炎肝郁血虚伴失眠症患者的临床疗效。方法:65例慢性乙型肝炎肝郁血虚伴失眠症患者随机分为两组,治疗组33例采用加味酸枣仁汤治疗,对照组32例采用舒乐安定及肝利欣护肝降酶治疗。观察治疗前后患者睡眠改善情况及对肝功能的影响。结果:两组均能有效改善患者的睡眠症状及肝功能,加味酸枣仁汤组患者经治疗1个月后睡眠的Ⅰ期、Ⅱ期睡眠明显减少,Ⅲ期、Ⅳ期、REM睡眠时间明显增加,睡眠结构与治疗前比较有显著性差异(P<0.05)。两组均能明显改善患者的肝功能,但在改善AST方面治疗组则明显优于对照组(P<0.05)。结论:加味酸枣仁汤对改善患者的睡眠结构具有明显调节作用,因而提高睡眠质量,副作用较少并且有护肝作用,适用于慢性肝病合并失眠患者。
Objective： To explore the effect of modified Suan Zao Ren Decoction（mediation decoction） on insomnia of chronic hepatitis B patients with stagnation of the Liver-Qi and deficiency of blood syndrome.Methods： Sixty-five patients of chronic hepatitis B with stagnation of the Liver-Qi,deficiency of the spleen and damp-heat syndrome were randomly divided into two groups.Thirt-three patients in the treatment group were treated by modified Suan Zao Ren Decoction,and thirty-two patients in the control group were treated by Surazepam and Diammonium Glycyrrhizinate.The clinical syndromes of insomnia and liver function were observed before and after treatment.Results： After one months of treatment,the main symptoms and signs of insomnia are improved in both groups,stage Ⅰand Ⅱ sleep decreaed significantly while stage Ⅲ,Ⅳ and rapid eye movement increased in insomniacs after treatment of modified Suan Zao Ren Decoction（P〈0.05）.The total effective rate was not significantly different between the two groups（P〉0.05）,while the markedly effective rate was significantly different（P〈0.05）.In the same time,ALT,AST,TB levels of two groups were obviously decreased（P〈0.01,P〈0.05）,AST levels of two groups after treatment were significant different（P〈0.05）.Conclusion： Modified Suan Zao Ren Decoction is effective for improving sleep composition,and therefore improve the quality of sleep with few side effect.In the same time,It has the function in improving liver function,and can be used to treat chronic hepatitis B patients with insomnia.
出处
《中药材》
CAS
CSCD
北大核心
2007年第11期1482-1484,共3页
Journal of Chinese Medicinal Materials
基金
广东省中医药管理局基金(No1050172)
广东省自然科学基金(No0630081)
关键词
加味酸枣仁汤
失眠
慢性乙型肝炎
Suan Zao Ren Decoction
insomnia
chronic hepatitis B
