摘要
目的：通过模拟高原缺氧复合梭曼中毒，观察缺氧、梭曼中毒复合效应的神经毒作用。方法：通过低压舱模拟３０００ｍ高原缺氧；梭曼皮下注射中毒造成不同程度的高原缺氧复合梭曼中毒的实验动物模型，以惊厥活动的定量分析为指标，观察神经毒效应；通过梭曼中毒有、无惊厥大鼠血气变化的对比研究，探讨惊厥与缺氧、代谢性酸中毒的关系。结果：①单纯模拟３０００ｍ米高原缺氧６ｈ在小鼠未诱发严重惊厥；②梭曼皮下注射中毒５０ｍｇ／ｋｇ剂量未诱发严重惊厥而１００μｇ／ｋｇ中毒则诱发严重惊厥；③梭曼中毒合并缺氧，复合效应表现为加重惊厥的协同作用；④惊厥可加重机体缺氧和代谢性酸中毒。结论：惊厥的定量分析可客观反映缺氧梭曼中毒复合效应的神经毒作用；惊厥可诱发缺氧和代谢性酸中毒，因此，抗惊厥治疗在拮抗神经毒作用，保护脑功能的措施中有其特殊重要意义。
Objective: To observe the neurotoxicity of hypoxia at high altitude in combination with soman intoxication. Methods: The experimental model of the combined injury was established in rats by simulating hypoxia in a hypobaric chamber and injecting various doses of soman subcutaneously. Quantitative analysis of seizure activities was used as the indicator of neurotoxicity of hypoxia alone or in combination with soman intoxication. Furthermore, the analysis of blood gas was comparatively conducted in rats with or without seizure after soman injection to elucidate the possible relationship between seizure activity and hypoxia. Results: ①No seizure was found in mice with hypoxia at a simulated altitude of 3,000 m; ②Severe seizure was found in those mice with injection of soman at a dose of 100 g/kg; ③hypoxia and soman intoxication acted in a synergistic manner to intensify seizure activity; ④Seizure resulted in severe hypoxia and metabolic acidosis. Conclusion: Soman intoxication alone or in combination with hypoxia at high altitude can exert remarkable neurotoxic effects. Therefore, treatment of seizure in cases of combined injury of hypoxia and soman intoxication plays an important role in protecting the brain from injury and antagonizing neurotoxicity.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1997年第3期187-190,共4页
Journal of Third Military Medical University
基金
全军"九五"攻关项目
日本屉川奖学金资助
关键词
缺氧
梭曼
神经毒
hypoxia
soman
neurotoxicity
seizure
rat
