摘要
缺氧性肺动脉高压的确切发病机理目前仍不甚清楚。本文以原位杂交技术观察了癌基因erbB在缺氧大鼠肺内的表达情况,结果发现缺氧7天后,大鼠肺组织内erbB mRNA表达明显增加(P<0.001),并一直持续至缺氧21天后,提示erbB癌基因可能与缺氧引起的肺血管结构的改建过程有关。
In order to assess whether there is any abnormality in oncogene expression in hypoxia induced pulmonary hypertension, the expression of oncogene erbB in the lung tissue of rats with and without hypoxia was detected by in situ hybridization with digoxingenin as a prob label. The results showed that there was a slight expression of erbB mRNA in control normoxic rats. After hypoxia for 7 to 21 days, its expression increased significantly as compared with that in control (P<0.001). It was proposed that the increased oncogene erbB mRNA expression might be related to the pulmonary arterial proliferation induced by chronic hypoxia.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1997年第3期249-252,共4页
Chinese Journal of Pathophysiology
