摘要
综述了2-氯烟酸的合成工艺,并提出了改进的工艺路线。3-氰基吡啶先经乙酰丙酮酸钼催化氧化得到烟酸N-氧化物,再经有机碱和苯磷酰二氯作用下,三氯氧磷氯化得到2-氯烟酸,总收率95.0%。
An improved synthetic process of 2-chloronicotinic acid was reported based on reviewing its synthetic processes in detail, 3-cyanopyridine was oxidized to nicotinic acid N-oxide using molybdenyl acetylacetonate as catalyst, and then chloridized to give the title product 2-chloronicotinic acid through chlorination by POCl3 in presence of organic base and phenyl dichlorophosphate （PDCP） . The total yield of 2-chloronicotinic acid was 95%.
出处
《精细化工中间体》
CAS
2007年第6期19-21,共3页
Fine Chemical Intermediates
关键词
2-氯烟酸
合成
乙酰丙酮酸钼
苯磷酰二氯
2-chloronicotinic acid
synthesis
molybdenyl acetylacetonate
phenyldichlorophosphate
