摘要
目的研究应用贝那普利、地尔硫对心脏X综合征(CSX)患者内皮功能的影响。方法将40例CSX患者随机接受贝那普利(20例,贝那普利组)或地尔硫(20例,地尔硫组)治疗,并设20例健康人为对照组,比较治疗前及治疗12周后对一氧化氮(NO)、内皮素-1(ET-1)及对肱动脉内皮依赖性舒张功能的影响。结果与正常对照组相比,CSX患者NO水平明显降低,ET-1水平明显升高,血管内皮依赖性舒张功能受损(均P<0.01)。用药后贝那普利组较用药前NO明显升高(54.15±19.48)μmol/L vs(70.25±17.46)μmol/L(P<0.01),地尔硫组用药后NO明显升高(55.69±16.32)μmol/L vs(59.17±14.92)μmol/L(P<0.05)。ET-1明显降低(70.61±6.22)ng/Lvs(55.18±4.71)ng/L(P<0.01),血管内皮依赖性舒张功能改善(4.60±2.40)%vs(10.60±2.50)%(P<0.01),地尔硫组较用药前ET-1明显降低(69.37±7.85)ng/L vs(62.94±6.38)ng/L(P<0.05),血管内皮依赖性舒张功能改善(4.70±2.30)%vs(6.40±1.90)%(P<0.05)。结论CSX患者存在血管内皮功能障碍,贝那普利与地尔硫均能改善CSX患者的内皮功能,且较地尔硫更为有效。
Objective To study the effect of benazepril and diltiazem on endothelium function in the patients with cardiac syndrome X. Methods Forty patients with cardiac syndrome X were randomly divided into benazepril group（group benazepril,20 cases） and diltiazem group （group diltiazem, 20 cases）,and 20 matched healthy subjects were enrolled as control group. The changes of serum activity of nitric oxide （NO）, endothelin-1 （ET-1） and endothelium-dependent relaxing function were measured before and after 12 weeks ＇treatment. Results Compared with those of control group, NO level and the flow mediated dilatation in brachial arteries were significantly decreased, and ET-1 was significantly increased in cardiac syndrome X group. NO in group benazepril before and after therapy was （54. 15±19.48） μmol/L vs （70.25±17.46） μmol/L （ P 〈0.01） ;that in group diltiazem were （55.69±16.32） μmol/ L before vs （59.17±14.92） μmol/L after therapy （ P 〈0.05） was increased. ET-1 in group benazepril was （70.61±6.22） ng/L before vs （55.18±4.71） ng/L after therapy （ P 〈0.01） ,than in group diltiazem was （69.37±7.85） ng/ L before vs （62.94±6.38） ng/L after therapy （ P 〈0.05）, which was significantly decreased. Endothelium-dependent relaxing function in group benazepril was （4.60±2.40）% before vs （10.60±2.50） % after therapy（ P 〈0. 01） ;that in group diltiazem was （4.70±2.30）% before vs （6.40±1.90）% after therapy （P 〈0.05）. Conclusion Both benazepril and diltiazem can improve the endothelium function in the patients with cardiac syndrome X,and benazepril may have a better effect than diltiazem.
出处
《临床荟萃》
CAS
北大核心
2008年第1期9-12,共4页
Clinical Focus
