摘要
目的:报告1例急性淋巴细胞白血病合并高嗜酸细胞综合征(ALL/Eo)患者并结合文献进行讨论.方法:男性患者17岁,因胸闷、低热1mo入院.除具有浅表淋巴结和脾脏肿大、胸骨压痛及骨髓原始幼稚淋巴细胞比例增高的ALL临床特点外,还具红斑性皮疹、血栓形成(脾)和心肌内膜纤维化典型HES的临床表现.结果:入院诊断ALL/Eo,由于经济困难放弃治疗,出院3mo后死亡.结论:ALL/Eo是一种罕见病例,一种独特的临床病理学类型,目前全世界报告有50余例.患者外周血持续性嗜酸细胞增高同时找不到幼稚淋巴细胞且无全血细胞减少,诊断时应全面考虑.
AIM： To report a case of acute lymphoblastic leukemia （ALL） complicated with hypereosinophilic syndrome （HES） （ALL/Eo） , and review the reported literatures. METHODS： A 17-year-old male patient was admitted to the hospital for chest distress and low-grade fever 1 month. Not only ALL clinical features, such as lymphadenectasis, splenomegaly, chest bone tenderness, higher proportion of immature lymphoblasts of bone marrow cells, but also typical clinical manifestations of HES, such as erythematous skin rash, thrombosis （ spleen）, endomyocardial fibrosis, were all observed. RESULTS： ALL/Eo was diagnosed for the patient at admission. The patient gave up treatment for the financial strait and died 3 months post-discharge. CONCLUSION： ALL/Eo is a rare disease. More than 50 patients with ALL/Eo have been reported by now in the world. The diagnosis needs comprehensive consideration.
出处
《第四军医大学学报》
北大核心
2008年第1期44-46,共3页
Journal of the Fourth Military Medical University
