摘要
目的:测定胃癌组织中细胞黏附分子CD44V6的表达水平并探讨其临床生物学意义。方法:应用流式细胞分析技术定量分析了96例手术切除的新鲜胃癌组织、癌旁正常胃黏膜组织及20例胃溃疡组织、溃疡旁正常胃黏膜组织中CD44V6的表达水平。结果:4种组织中均有CD44V6的表达,但胃癌组织中CD44V6的阳性率(64.5%,62/96)明显高于癌旁正常胃黏膜组织(27.1%,26/96)、胃溃疡组织(25.0%,5/20)及溃疡旁正常胃黏膜组织(20.0%,4/20),P<0.05;CD44V6的表达水平与肿瘤浸润深度、淋巴结转移、远处转移有关(P<0.05),且与肿瘤pTNM分期关系密切(P<0.001)。结论:CD44V6高水平表达可能意味着胃癌恶性程度较高且病期较晚,测定胃癌组织中CD44V6的水平对判断胃癌浸润、转移及病期进展情况有一定的诊断价值。
Aim： To detect the expression of cell adhesion molecule CD44V6 in gastric cancer tissue and investigate its clinical significance. Methods ：Flow cytometry was used to detect the expression of CD44V6 in 96 cases of gastric cancer tissue and 20 cases of gastric ulcer tissue as well as their corresponding normal stomach mucosa tissue. Results： Positive expression of CD44V6 was detected in the above 4 kinds of tissue. Positive expression rate of CD44V6 in gastric cancer （64.5% ,62/96） was significantly higher than those in normal stomach mucosa adjacent to cancer（27.1% ,26/96） ,ulcer （25.0% ,5/20） ,and the normal tissue adjacent to ulcer （20.0% , 4/20） , respectively, P 〈0.05. The expression level of CD44V6 in gastric cancer was related to the depth of tumor infiltration, lymph node metastasis, distant metastasis and TNM clinic-pathological staging （ P 〈 0.05） , respectively. Conclusion ： The detection of CD44V6 expression in gastric cancer is helpful to estimate tumor invasion, metastasis and tumor staging, and higher expression of CD44V6 always suggests poor clinical properties and later TNM stages of gastric cancer.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2008年第1期136-139,共4页
Journal of Zhengzhou University(Medical Sciences)
