摘要
目的探讨经导管室间隔缺损(VSD)封堵术治疗前后心肌酶谱及心功能的变化。方法检测VSD患儿介入治疗前后血清肌钙蛋白(cTnI)、磷酸肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、AST水平,并通过超声心动图(UCG)测定其左室射血分数(LVEF),对治疗前后资料进行对比分析。应用SPSS10.0软件进行统计学分析。结果介入治疗后VSD患儿较治疗前血清cTnI明显升高[(0.29±0.17)μg/Lvs(0.02±0.01)μg/L,t=9.0P<0.01],LVEF有所降低[(75.4±5.1)%vs(78.3±6.2)%,t=2.14P<0.05],血清CK、CK-MB、LDH、AST水平无明显变化(t=0.15,0.46,0.89,0.45Pa>0.05)。结论经导管VSD封堵术对患儿心肌酶及心功能有一定影响。予以相应的干预治疗仍是必要的。
Objective To explore the changes of cardiac muscle enzymogram and heart function before and after transaetheter closure of Ventrieulax septal defect （VSD）. Methods The serum levels of cardiac troponin （cTnI） , eareatine kinase （CK） , lactic dehydrogenase （ LDH ）, aspartate aminotransferase（AST） and the left ventrieular ejection fraction（LVEF） were detected by two -dimensional eehoeardiography,and the eharige before and after intervention was analyzed. Results The serum level of eTnI in VSD patients after treatment was markedly higher than that before intervention[ （0.29 ±0.17）μg/Lvs （0.02±0.01）μg/L,t=9.0 P〈0.01],The LVEF deereasedafter intervention [（75.4±5.1）% vs （78.3±6.2）%,t=2.14 P〈0.05].The levels of CK,CK-MB,LDH,ASTeoneotrationshadnosignifieantdifferenee between the patients before and after intervention（ Pa 〉 0.05 ）. Conclusion Catheterization tO treat VSD may have influence on enzymogram and the heart function ,which may be related to the minor myocardial damage during the operation.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2008年第1期48-49,共2页
Journal of Applied Clinical Pediatrics
关键词
心肌酶谱
心功能
室间隔缺损
介入治疗
enzymogram, cardiac muscle
heart function
ventricular septal defect
intervention treatment
