摘要
采用自由基溶液聚合和连续的互穿网络技术,以氧化还原引发体系为引发剂、化学交联聚丙烯酸(PAA)和聚乙烯醇(PVA)制备了一系列PAA/PVA水凝胶膜。ATR-FTIR光谱表明,网络组成之间形成了新的相互作用的氢键,DSC分析表示网络组成具有良好的热力学相容性。膜在各种介质中的溶胀性质表明:因PAA的亲水性强于PVA,溶胀比随PAA的增多而提高。以阳离子化合物结晶紫为模板药物考察了在不同的pH缓冲溶液中的释放行为,结果表明,药物的释放能力可以通过改变体系的pH值加以调控。
A series of PAA/PVA full-IPNs hydrogel films were prepared using radical solution polymerization and sequential interpenetrating network technology by redox initiating system and chemical crosslink for PAA and PVA. And ATR-TR analysis showed that new hydrogen bonds interaction formed in IPNs systerrL A single Tg of DSC curves indicated that there was good miscibility between network compositions. The swelling characterization of films showed the swelling ratio increased with an increasing of PAA content in IPN films in various media due to more hydrophilicity of PAA than PVA. Cationic compound erystal violet as model drug its release behavior was investigated in different pH buffer solution. The results showed that the release capacity can be adjusted by changing systematic pH.
出处
《化工新型材料》
CAS
CSCD
北大核心
2007年第12期37-39,共3页
New Chemical Materials
关键词
互穿网络
水凝胶
膜
PH敏感性
药物释放
interpenetrating polymer network, hydrogel, film, pH sensitivity,drug release
