摘要
目的探讨葡萄糖转运蛋白(GLUT1)和血管内皮生长因子C(VEGF-c)与胃黏液腺癌浸润转移的关系。方法采用免疫组化S-P法,检测60例胃黏液腺癌患者的正常胃黏膜组织、癌旁组织、黏液腺癌组织中GLUT1和VEGF-c蛋白的表达。结果GLUT1和VEGF-c蛋白的表达与胃黏液腺癌的浸润深度及淋巴结转移显著相关(P<0.05)。结论GLUT1和VEGF-c蛋白的过度表达,可能共同参与了胃黏液腺癌的局部浸润及早期淋巴结转移。
Objective To explore the relationship between the expression of glucose transporter-1 （GLUT1）,vascular endothelial growth factor-c （VEGF-c） and the infiltration,metastasis of gastric cancer. Methods The expression of GLUT1and VEGF-c in the normal mucous membrane,paracancerous tissues and cancer tissues was evaluated using S-P immunohistochemieal method in 60 patients with gastric mucinous carcinoma. Results The expression of GLUT1 ,VEGF-c was positively correlated to the depth of tumor infiltration and the lymph node metastasis in mutinous adenoearcinoma of stomach. Conclusion The overexpression of GLUT1 and VEGF-c proteins may involve in the local infiltration and lymph node metastasis in mucinous adenocarcinoma of stomach.
出处
《实用癌症杂志》
2008年第1期25-27,共3页
The Practical Journal of Cancer
关键词
胃肿瘤
黏液腺癌
葡萄糖转运蛋白
血管内皮生长因子-C
免疫组化
Gastric tumor
Mutinous adenoearcinoma
Glucose transporter-1 （ GLUT1 ）
Vascular endothelial growth faetor-c （VEGF-c）
lmmunohistoehemistry
