摘要
目的苦参碱注射液对婴儿巨细胞病毒性肝炎患者肿瘤坏死因子-α（TNF-α）的影响。方法将42例婴儿巨细胞病毒（CMV）肝炎患儿随机分为苦参碱治疗组（n=22）与更昔洛韦对照组（n=20）。两组均予以常规保肝降酶治疗为基础。苦参碱治疗组用苦参碱注射液20-25mg/d静脉滴注,每日1次,连用14天;间隔7-10天后20-25mg/kg.d静脉滴注,每日1次,连用5天,共2-3个疗程。更昔洛韦对照组用更昔洛韦5mg/kg.d静脉滴注,每日2次,连用14天;间隔7-10天后5mg/kg.d静脉滴注,每日1次,连用5天,共2-3个疗程。观察两组TNF-α水平变化。结果治疗前、后苦参碱注射液对血TNF-α、TBIL、ALT的变化。（P〈0.01）。结论苦参碱注射液治疗婴儿巨细胞病毒性肝炎疗效确切,可能与抑制TNF-α释放有关。
Objective：To observe the treatment of infants＇ Cytomegalovirus hepatitis with Matrlne injection.Methods：Fourty-two cases of CMV hepatitis were randomly divided into tow groups： the treated group（n =22） and the control group（n = 20）.The treated group with Matrlne（25 mg/ d） once daily for 14 days.After 7～10 day with Matrlne（25 mg/ d） once daily for 5 days.Then repeat 2～3 time.The control group with Ganciclovir 5md/kg·d twice daily for 14days.After 7～10 day with Ganciclovir 5md/kg·d twice daily for 5 days,then repeat 2～3 time.Results：There were significant differences in IBIL and TBA between the two groups after two weeks（P〈0.05）.There were very significant differences in time of initial jaundice disappearance and complete disappearance after two weeks（P〈0.01）.Conclusion：As enitial Ademetionine,Transmetil could supplement absenced endogenesis Ademetionine,efficiencly decrease intestines-liver ciculation,protect scathing liver cell,accelerate jautice fadeaway.
出处
《中国优生与遗传杂志》
2008年第1期116-117,共2页
Chinese Journal of Birth Health & Heredity
基金
广东省中医药局2060023的立项
