摘要
目的:探讨地红霉素对轻中度哮喘儿童支气管高反应性的影响。方法:轻中度哮喘儿童50例,用布地奈德吸入(剂量为轻度哮喘100μg·d^(-1),中度哮喘200μg·d^(-1))4周后,分为A、B两组,进入试验观察。所有病例继续应用糖皮质激素吸入,剂量同前。A组26例,加用地红霉素5mg·kg^(-1),po,每周2次。B组24例,单用布地奈德吸入。试验期为8周。两组在试验开始和结束时均用诱导痰液进行淋巴细胞百分率、嗜酸粒细胞百分率、中性粒细胞百分率检测。结果:A组其诱导痰液的淋巴细胞、中性粒细胞百分率与B组比较,均有统计学差异(P<0.05)。结论:小剂量地红霉素口服8周,并联合吸入糖皮质激素治疗轻、中度哮喘儿童的支气管高反应性明显降低。
Objective： To investigate the effects of Dirithromycin on bronchial hyperresponsiveness in children with mild and moderate asthma. Method ： After treatment with budesonide （ at doses of 100μg·d^-1 with mild , 200μg·d^-1 with moderate asthma） for four weeks, fifty cases with asthma were divided into two groups. All children with asthma in two groups continued the treatment of corticosteroids at doses of above. Group A 26 cases combined with dirithromycin orally twice a week at a dose of 5mg·kg^-1. Group B 24 cases used badesonide only. The period of treatment was eight weeks. The percentage of lymphocytes, eosinocytes and neutro-granulocytes were measured through induced sputum at the beginning and the end of treatment. Result： The percentage of lymphocytes, eosinocytes and neutro-granulocytes in group A were statistical difference compared with that in group B（ P 〈 0.05）. Conclusion： The treatment of inhaled corticosteroids combined low dose administration of dirithromycin for eight weeks in children with mild and moderate asthma can reduce bronchial hyperresponsiveness.
出处
《中国药师》
CAS
2008年第1期78-79,共2页
China Pharmacist
关键词
地红霉素
哮喘
儿童
支气管高反应性
Dirithromycin
Asthma
Children
Bronchial hyperresponsiveness
