摘要
目的：探讨奥曲肽防治应激性溃疡的确切机制．方法：对大鼠严重脑损伤后应激性胃粘膜损害，给予两种不同剂量的奥曲肽（４μｇ·ｋｇ－１·１２ｈ－１和６μｇ·ｋｇ－１·１２ｈ－１）治疗，测定胃粘膜血流（ＧＭＢＦ）等多项指标，与等渗盐水对照组、正常对照组、法莫替丁治疗组进行比较．结果：奥曲肽治疗能显著降低胃粘膜损伤指数（Ｐ＜０．０１），增加ＧＭＢＦ（Ｐ＜０．０１），升高胃粘膜电位（Ｐ＜０．０１），增加胃粘膜氨基已糖、磷脂含量（Ｐ＜０．０１）．结论：奥曲肽具有良好的胃粘膜细胞保护作用，对防治大鼠重度脑损伤后所致胃粘膜损害具有良好疗效．
Aim: To study the mechanisms of octreotide on preventing and treating stress ulcer. Methods: Two different dose of octreotide (4μg·kg -1 ·12h -1 or 6μg·kg -1 ·12h -1 ) was used separately to rats which were inflicted irritable gastric mucosal injury after serious brain trauma. Gastric mucosal blood flow (GMBF) and other indexes were measured. Results: Compared with control gorup, octreotide could lessen injury index ( P <0.01), increase GMBF ( P <0.01), elevate electrical potential difference ( P <0.05), and contents of hexosamine and phospholipids in gastric mucosa ( P <0.01). Conclusion: Octreotide has protective effects on gastric mucosa. It is advisable for the treatment of gastric mucosal injury after serious brain trauma in rats.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
1997年第4期232-234,共3页
Chinese Journal of Trauma
关键词
奥曲肽
脑损伤
应激性溃疡
胃粘膜细胞
保护
Octreotide Brain trauma Stress ulcer Gastric mucosal cytoprotection
