摘要
目的探讨性激素受体与异位妊娠发生之间的关系。方法选择输卵管妊娠组25例、正常输卵管组27例及正常宫内早孕组28例,采用免疫组化染色技术检测输卵管妊娠黏膜组织、正常输卵管黏膜组织及正常宫内早孕组子宫蜕膜组织中雌激素受体(ER)及孕激素受体(PR)的表达。结果ER和PR阳性表达在正常宫内早孕组最高,在输卵管妊娠组中较高,在正常输卵管组中最低,3组两两比较差异均有统计学意义(P<0.05)。结论妊娠输卵管黏膜组织ER和PR含量较低,导致输卵管发育和肌层蠕动功能与生殖活动不相适应,使得受精卵滞留于输卵管,可能是发生输卵管妊娠的因素之一。
Objective To explore the relationship between estrogen receptor（ER）, progesterone receptor（PR） and tubal pregnancy. Methods Expression of ER and PR in tubal pregnancy group（ n = 25）, normal oviduct group（ n - 27） and early pregnant uterin group（ n = 28） was detected by immtmohistochemistry and analyzed by semi-quantity pathologic image analysis. Results The positive expression of ER and PR in tubal pregnancy group was significantly higher than that in normal human oviduct group（ P 〈 0.05）, but significantly lower than that in early pregnant uterin group（ P 〈 0.05）. Conclusion Low expression of ER and PR in oviductal mucosa of tubal pregnancy would lead to the inadaptation of tubal development and peristalsis to the needs of reproduction, which would result in the blastocyst implantation in the oviduct and the occurrence of tubal pregnancy.
出处
《山西医科大学学报》
CAS
2008年第2期180-182,共3页
Journal of Shanxi Medical University
基金
郧阳医学院研究生启动基金资助项目(2006QDJ11)
关键词
妊娠
输卵管
受体
雌激素
受体
孕激素
pregnancy, tubal
receptors, estrogen
receptors, progesterone
