摘要
目的:探讨肝细胞生长因子(hepatocyte growth factor,HGF)、基质金属蛋白酶-2(matrix metalloproteinase,MMP-2)和MMP-9在胰腺癌组织中的表达及其临床意义。方法:采用免疫组化SP方法检测50例胰腺癌组织和10例正常胰腺组织中HGF、MMP-2、MMP-9的表达,并分析三者与胰腺癌临床病理特征间的相互关系。结果:胰腺癌组织中HGF、MMP-2和MMP-9的表达与正常胰腺组织相比,差异有统计学意义(P<0.01,P<0.05,P<0.01)。且三者的表达水平与胰腺癌临床分期及淋巴结转移相关。HGF与MMP-2、MMP-9的表达有相关性(P<0.05,P<0.05)。结论:HGF、MMP-2、MMP-9在胰腺癌组织中呈高表达,表达水平与胰腺癌临床分期和淋巴结转移密切相关;HGF与MMP-2、MMP-9间的表达具有协同作用,共同促进胰腺癌的侵袭和转移。
Objective：To study the expression and significance of HGF, MMP-2 and MMP-9 in pancreatic carcinoma. Methods：The expression of HGF, MMP-2 and MMP-9 were examined by immunohistochemical technique in 50 cases of pancreatic carcinomas and 10 cases of normal tissues. The relationship between the expression and tumor behaviors were also analyzed. Results：The expressions of HGF, MMP-2 and MMP-9 in pancreatic carcinoma and normal tissues had distinct differences （P 〈0.01, P 〈0.05 , P 〈0.01）. The exprssions of them in pancreatic carcinoma were significantly associated with the clinicopathologic stage and lymph node metastasis. The expression of HGF was positively associated with MMP-2 and MMP-9 expression （P 〈0.05, P 〈0.05）. Conclusion：HGF, MMP-2 and MMP-9 are all over expressed in pancreatic carcinoma.The expression of HGF, MMP-2 and MMP-9 is closely correlated with lymph node metastasis and clinicopathologica stage.The expression between HGF and MMP-2 , MMP-9 has a closely relationship, they have a co-operated effect.
出处
《中国现代普通外科进展》
CAS
2008年第1期29-31,39,共4页
Chinese Journal of Current Advances in General Surgery
关键词
胰腺肿瘤
肝细胞生长因子
基质金属蛋白酶
Pancreatic neoplasma· Hepatocyte growth factor· Matrix metalloproteinase
