摘要
目的研究在多省市35～64岁人群中正常高值血压的分布情况,分析正常高值血压[SBP130～139mmHg及(或)DBP85～89mmHg]与心血管病(CVD)发病危险的关系。方法在中国多省市前瞻性队列研究数据基础上,对1992年建立的11省市35～64岁队列人群共30378人的基线血压水平和1992-2003年期间发生的CVD[包括冠心病(CHD)和脑卒中]事件的关系进行分析。结果1)我国35～64岁人群中正常高值血压者占32.1%,与高血压的比例为1.2:1.0。2)多因素分析显示:以正常血压为对照,正常高值血压增加脑卒中发病危险56%(RR=1.559;95%CI1.163,2.089);增加CHD发病危险44%(RR=1.441;95%CI0.996,2.086);增加总的CVD发病危险52%(RR=1.522,95%CI1.206,1.919)。正常高值血压对出血性卒中的作用(RR=2.082,95%CI1.116,3.885)大于对缺血性卒中的作用(RR=1.474;95%CI1.050,2.069)。3)在总的CVD事件中,14.4%归因于正常高值血压;其中12.4%的CHD事件和15.2%的脑卒中事件归因于正常高值血压。结论我国35～64岁人群中正常高值血压比例很高。正常高值血压增加人群脑卒中和CVD发病危险。对正常高值血压人群采用生活方式干预具有重要的公共健康意义。
Objective To study the prevalence and distribution of high-normal blood pressure （SBP 130- 139 mm Hg, and/or DBP 85-89 mm Hg） in Chinese population aged 35-64 years and the association of high- normal BP with risk of cardiovascular diseases（CVD）. Methods A prospective study was carried out in 11 provinces from 1992 to 2003. The association of baseline blood pressure level and cardiovascular disease events was analyzed in 30 378 subjects aged 35-64 years using Cox multivariate proportional hazards regression. Results 1）The prevalence rate of high-normal BP was 32.1% in this cohort of population. High-normal BP： sustained hypertension prevalence ratio was 1.2 ： 1.0. 2） Compared with normotensives, multivariate analysis revealed that high normal BP increase total cardiovascular disease by 52% （RR=1. 522, 95% CI 1. 206, 1. 919）, increase coronary heart disease by 44% （RR=1. 441;95% CI： 0. 996, 2. 086）and increase stroke by 56% （RR=1. 559; 95% CI： 1. 163, 2. 089）in the subjects with high-normal BP. The impact of high-normal BP was greater on hemorrhagic stroke （RR=2. 082;95% CI 1. 116, 3. 885）than on ischemic stroke （RR=1. 474;95% CI 1. 050, 2. 069）. 3） 14.4% of total CVDs, 15.2% of the acute stroke and 12. 4% of the acute CHD could be attributed to high-normal blood pressure. Conclusion High-normal blood pressure was common in Chinese population aged 35-64 years, which independently associated with increased risk of cardiovascular disease. Lifestyle modifications for population with high-normal blood pressure are strongly advocated.
出处
《中华高血压杂志》
CAS
CSCD
北大核心
2007年第12期984-987,共4页
Chinese Journal of Hypertension
基金
"八五"国家科技攻关课题(85-915-01-02)
北京心血管高技术实验室资助项目(953850700)
关键词
心血管病
血压
正常高值
前瞻性研究
Cardiovascular diseases
Blood pressure
High-normal blood pressure
Pre-study
