摘要
目的观察宁脂胶囊对2型糖尿病高脂血症患者血脂谱的影响。方法采用随机平行对照研究。共纳入符合2型糖尿病气阴两虚、痰瘀互阻型高脂血症患者70例,分为两组。中药组给予宁脂胶囊5粒,每天3次口服;对照组根据血脂成分的不同分别给予贝特类和他汀类的药物治疗;原用的降糖降压药物维持不变。治疗过程中因药物不良反应退出2例,失访8例(中药组4例,西药组4例)。疗程6个月,疗程结束时资料完整60例。结果中药组治疗后,患者胆固醇、甘油三酯、低密度脂蛋白载脂蛋白B及脂蛋白(a)的水平降低、高密度脂蛋白及载脂蛋白A的水平提高,与治疗前比较,差异均有统计学意义(P<0.05,P<0.01);与西药组(除高密度脂蛋白外)治疗后比较,差异均无统计学意义(P>0.05)。中药组治疗后中医症状积分亦明显下降(P<0.01);血、尿常规,肝肾功能无明显变化。结论宁脂胶囊具有改善糖尿病高脂血症患者的血脂谱及中医症状的作用。
Objective To observe the effect of Ningzhi Capsule （NZC） on blood lipid spectrum in type 2 diabetes mellitus patients complicated with hyperlipemia （DM-HL）. Methods Adopting randomized, parallel and controlled trail method, a total of 70 DM-HL patients of qi-yin deficiency and phlegm-blood stagnant syndrome type were randomized into two groups. The original medication for lowering blood sugar and blood pressure was unchanged, the trial group received oral administration of NZC 5 tablets, 3 times a day, while the control group received Lipanthgl or Simvastatin depending on their different constituents of blood lipids. After 6 months of treatment, sixty subjects completed the trail while two patients dropped out due to side effect and 8 patients lost followup （4 in each group）. Levels of blood lipids, blood routine, liver and kidney function and symptoms in patients were detected and compared. Results After treatment, levels of total cholesterol （TC）, triglyceride （TG）, lowdensity lipoprotein （LDL-C）, apoprotein B, and lipoprotein a （LPa） lowered, while levels of high-density lipoprotein （HDL-C） and apoprotein A raised in the trial group as compared with those before treatment （ P 〈 0. 05, P 〈 0. 01 ）, but showed no difference between the two groups after treatment except HDL level （ P 〉 0. 05 ）. Scores of symptoms were also lowered significantly in the trial group （ P 〈 0. 01 ）. In the observation period, no abnormal findings in blood and urine routine examination as well as in liver and renal function were found. Conclusion NZC could lower the blood lipid spectrum and improve the TCM symptoms in DM-HL patients without any adverse reaction.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2008年第2期118-121,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家中医药管理局基金资助项目(No.02-03-LL04)
关键词
宁脂胶囊
2型糖尿病
高脂血症
血脂谱
Ningzhi Capsule
type 2 diabetes mellitus
hyperlipemia
blood lipid spectrum
