摘要
采用超声乳化溶剂蒸发法制备了阿奇霉素超细粉体,讨论了溶剂、温度、稳定剂种类及用量、阿奇霉素浓度等对微粉粒径的影响,优化了实验条件。实验结果表明:在最佳实验条件下(丙酮/水为2/3,阿奇霉素质量浓度为16.33g/L,0.667%聚乙二醇6000,温度为25℃),可制备出平均粒径为1.0μm的均匀分散的阿奇霉素超细粉体;红外分析表明本方法未改变样品的化学结构。
Uhraflne particles of Azidaromycin were produced by ultrasonic emulsifieation- solvent evaporation. The affecting factors including solvent, stabilizer, time and temperature on the average size af the product were studied. The optimal producing condition was that in the presence of PEG6000 of 0.667% at 25℃, the concentration of Azidaromyein was 16.33g/L with the ratio of aeetoned water of 2/3 with aging time of lb. Under the optimal condition, the average size of particles was 1.0μn with the narrow distribution and the chemical structure of Azithro- myein sample was not changed.
出处
《茂名学院学报》
2008年第1期20-23,共4页
Journal of Maoming College
关键词
阿奇霉素
溶剂蒸发
超细粉体
超声乳化
Azithromycin
solvem evaporation
microparticle
ultrasonic emulsification
