摘要
目的观察黄芪对慢性低O2高CO2大鼠学习记忆能力的影响。方法雄性SD大鼠30只,随机分为对照组、低O2高CO24周组(模型组)、低O2高CO24周+黄芪治疗组(黄芪组)。用Morris水迷宫检测大鼠学习记忆能力,并测定海马组织中超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量。结果模型组与对照组比较,逃避潜伏期明显延长,且SOD活性明显降低和MDA含量明显升高(P<0.01)。黄芪组与模型组比较,大鼠逃避潜伏期明显缩短,且SOD活性明显升高和MDA含量明显降低(P<0.01)。结论黄芪可改善慢性低O2高CO2大鼠学习记忆能力,其作用机制与SOD活性升高和MDA含量降低有关。
Objective To investigate the protective effect of astragalus root（AR） on learning - memory ability in chronic Hypoxie Hypereapnia rats. Methods Thirty male SD rats were randomly divided into control group, hypoxia- hypereapnia group （model group） and hypoxia- hypereapnia combined with AR group （AR group）.Their learning- memory ability was evaluated by Morris water maze. The aetivities of superoxidedimutases （SOD） and the contents of malondialdehyde （MDA）were tested. Results Compared with control group, the escaping latenee were prolonged, SOD activities were decreased and MDA contents were increased significantly in model group. Compared with model group, the escaping latenee were shortened, SOD activities were increased and MDA contents were decreased significantly in AR group. Conclusion AR can improve learning- memory ability in chronic hypoxie hypercapnia rats. The mechanism is related with increased SOD activities and decreased MDA contents.
出处
《中国热带医学》
CAS
2008年第1期28-29,共2页
China Tropical Medicine
