摘要
目的：对122例血小板减少症患者输注1单位单采血小板效果的实验室观察。方法：按血小板输血史将患者分为3组，A组（首次输血者，41例）；B组（重复输血者，69例）；C组（频繁输血者，12例）。血小板输注1h和24h后，比较患者校正血小板计数增加值（CCI）和血小板回收率（PPR）。结果：A组、B组、C组间CCI、PPR差异有统计学意义（P〈0．05）；血小板减少症组血小板输注无效率低于血液病组。结论：单采血小板输注是临床控制出血重要方法，尤其对首次输血者及一般重复输血者（2～10次）有效，可起到更好的预防及治疗效果；频繁输血者（≥11次）输注血小板后疗效较低，可能与患者输血前血小板基数较低及频繁输血导致血小板输注无效有关，未来的研究需要收集患者临床资料以更好地把握此类患者血小板输注效果。
Objective：To observe the effect of one unit apheresis platelet（PLT） transfusion in 122 thrombocytopenia patients. Methods：According to the history of PLT transfusion, all patients were divided to three groups as Group A （First PLT transfusion）,Group B （Repeated PLT transfusion） and Group C （Frequent PLT transfusion）. We compared corrected count increment （CCI） and percentage platelet recovery （PPR） after one hour and 24 hours of transfusion for each group. Results：There were no significant differences of CCI and PPR between Group A, Group B and Group C （P〈0.05）. The rate of platelet transfusion refractoriness in thrombocytopenia group was lower than that in hematologic disease group. Conclusion： Apheresis PLT transfusion is an effective method to reduce bleeding and increase the effectiveness of clotting factors for most patients, especially in Group A and/or Group B. It is ineffective in Group C, possibly because of platelet transfusion refractoriness in patients received large number of apheresis PLT. It is necessary to collect the bedside date of these patients received apheresis PLT frequently in order to assure the effect of apheresis PLT in the future.
出处
《临床血液学杂志（输血与检验）》
CAS
2008年第1期88-89,共2页
Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)
