期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

他汀类药物非调脂作用的研究进展 被引量：14

在线阅读 下载PDF
导出
摘要 现代最重要的流行病学研究Framingham心脏病前瞻性研究和多重因素干预试验（MRFIT）证实：血脂水平是动脉粥样硬化和冠心病发病因素中最重要的危险因素之一．而应用调脂药物降低血浆总胆固醇（TC）或低密度脂蛋白胆固醇（LDL-C），将是控制动脉粥样硬化与冠心病的重要手段之一。
作者 李虹伟 彭晖
机构地区 首都医科大学附属北京友谊医院
出处 《临床药物治疗杂志》 2008年第2期47-51,共5页 Clinical Medication Journal
关键词 非调脂作用 他汀类药物 低密度脂蛋白胆固醇 动脉粥样硬化 血浆总胆固醇 调脂药物 危险因素 发病因素
分类号 R972.6 [医药卫生—药品] R589.2 [医药卫生—内分泌]
  • 相关文献

参考文献18

  • 1[1]Blumenthal RS.Statins:effective antiatherosclerotie therapy.Am Heart,2000,139:577
  • 2[2]Calabro P,Yeh TH.The phiotropie effects of statins.Curr Oplin Cardiol,2005,20(6):541-546
  • 3[3]Planavila A,Laguna JC,Vazquez-Carrera M,et al.Atorvastrtin improves peroxisome prolifecator-activated receptor Sighting in cardiac hypertrophy by preventing nuclear factor-kB activation.Biochimiea Biophysica Acta,2005,1687:76-83
  • 4[4]West of Scotland Coronary Prevention Study Group.Influence of pravastatin and plasma lipids on clinical events in the West of Scodand Coronary Prevention Study(woscoPs).Circulation,1998,97:1440-1445
  • 5[5]DOWNS JR.Primary prevention ofacute coronary events with lovastatin in men and women with average cholesterol levels:results of AFCAPS/TexCaps.Air Force/Texas Coronary Atheroselerosis Prevention Study.JAMA,1998,299:1615-1621
  • 6[6]The Scandinavian Simvaatatin Survival StudyGroup.Ran domized trail of lowering in 4444 patients with coronary heart diease:Scandinavian Simvastatin Survival Study(4S).Lancet,1994,344:1383-1389
  • 7[7]Sacks FM,Pfeffer MA,Move LA,et al.The effect of pravestatin on coronaryevents after myocardial infarction inpatients with average cholesterol levels.N Engl J Med,1996,335:1001-1009
  • 8[8]The Long term Intervention with Pravastatin in Isehemie Di seas (LIPID)Study Group.Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and abroad range of initial cholesterol levels.N Engl J Med,1998,339:1349-1357
  • 9[9]Kishi T,Hirooka Y,Mukai Y,et al.Atorvastatin causes depressor and sympathy inhibitory effects with upregulation of nitric oxide syntheses in stroke-prone spontaneously hypertensive rms.J Hypertension,2003,21:379-386
  • 10李志强,郑兴.炎症与冠心病[J].中国心血管病研究,2006,4(3):233-235. 被引量：38

二级参考文献41

  • 1杨映波 王正国 等.一种分离循环内皮细胞的新方法[J].中国药理学与毒理学杂志,1994,8(1):29-29.
  • 2[1]Ross R.Atherosclerosis-an inflammation disease.N Engl Med,1999,340:115-126.
  • 3[2]Massberg S,Brand K,Gruner S,et al.A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation.Exp Med,2002,196:887-896.
  • 4[3]Boring L,Gosling J,Cleary M,et al.Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis.Nature,1998,394:894 -897.
  • 5[4]Gupta S,Pablo AM,Jiang X,et al.IFN-gamma potentiates atherosclerosis in apoE knock-out mice.Clin Invest,1997,99:2752-2761.
  • 6[5]Mallat Z,Corbaz A,Scoazec A,et al.Interleukin- 18/interleukin-18 binding protein signaling modulates atherosclerotic lesion development and stability.Circ Res,2001,89:E41-E45.
  • 7[6]Ludewig B,Freigang S,Jaggi M,et al.Linking immunemediated arterial inflammation and cholesterol-induced atherosclerosis in a transgenic mouse model.Proc Natl Acad Sci USA,2000,97:12752-12757.
  • 8[7]Robertson AKL,Rudling M,Zhou X,et al.Disruption of TGF-beta signaling in T cells accelerates atherosclerosis.J Clin Invest,2003,112:1342- 1350.
  • 9[8]Binder C J,Hrkk S,Dewan A,et al.Pneumococcal vaccination decreases atherosclerotic lesion formation:molecular mimicry between Streptococcus pneumoniae and oxidized LDL.Nat Med,2003,9:736-743.
  • 10[9]Witztum JL.Splenic immunity and atherosclerosis:a glimpse into a novel paradigm.Clin Invest,2002,109:721-724.

共引文献120

同被引文献112

引证文献14

二级引证文献75

临床药物治疗杂志
2008年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部