摘要
百草枯(PQ)中毒可以导致全身多器官损伤,以肺部受损最为严重,肾上腺皮质激素有稳定细胞膜、对抗脂质过氧化、抗炎和非特异性免疫抑制作用,能有效清除肺间质水肿和预防肺纤维化,已成为治疗百草枯致急性肺损伤患者的重要综合措施之一,但有关激素的给药时机、具体用量、给药途径及疗程等还需进一步研究。
Paraquat poisoning can cause the injury of many organs. The lung is one of the primary target organs of paraquat. Adrenocortical hormones has antiinflammatory and antifibrotic actions and can also attenuate the injury of oxygen free radicals. Its use in the treatment of paraquat - induced acute lung injury are recommended and most important therapy. However, the most appropriate regimen such as dosage, how long and treatment course remains controversial. Recent studies on the pathogenesis of paraquat -induced acute lung injury are reviewed in this paper.
出处
《中国急救医学》
CAS
CSCD
北大核心
2008年第2期170-172,共3页
Chinese Journal of Critical Care Medicine
