摘要
学术背景:研究表明环孢素A具有强免疫抑制作用,目前已被广泛应用于临床器官移植领域。目的:综合分析近年来环孢素A的免疫抑制作用及其途径。检索策略:应用计算机检索,以北京大学医学图书馆网络数据库资源为主,查询Science Direct Onsite,ProQuest,Springer,Ovid等数据库1990-01/2006-12有关环孢素A免疫抑制机制方面的文章,检索词为"cyclosporineA,mechanism/action,immunosuppression",并限定文章语言种类为English。初检得到68篇文献,阅读标题和进行初筛。纳入标准:文章所述重点与环孢素A的免疫抑制机制相关。排除标准:重复研究。共50篇文章符合纳入标准,取其中有关气管移植的46篇文献进一步查找全文归纳总结。文献评价:46篇文献中6篇涉及环孢素A已知的临床应用和效果,40篇涉及环孢素A的分子生物学机制。资料综合:通过文献回顾,发现环孢素A免疫抑制机制集中于以下方面:①钙神经蛋白/活化的T细胞核因子途径方面的作用。②对JNK与P38信号通路的作用。③其他作用。结论:环孢素A一方面选择性地调节淋巴细胞亚群的功能;另一方面抑制T毒性细胞的活化,还可能抑制T记忆细胞的形成或反应。但它不影响T抑制细胞亚群的活化与增殖,对T抑制细胞表达白细胞介素2受体无影响,从而导致了选择性的免疫抑制。
BACKGROUND： Cyclosporine A has shown its immunosuppressive effects and has been widely used in clinical organ transplantation.
OBJECTIVE： To review the recent studies on the immunosuppressive mechanisms and the active pathway of cyclosporine A.
RETRIEVAL STRATEGY： A compute-based online search of ScienceDirect Onsite, ProQuest, Springer and Ovid, based on the data from Peking University Medical Library, was undertaken for the English articles concerning with the immunosuppressive mechanism of cyclosporine A from January 1990 to December 2006, with the keywords of “cyclosporine A, mechanism/action, immunosuppression”. Totally 68 articles were collected after the first trial, and the preliminary screening was conducted for the titles and abstracts. Inclusion criteria： articles related with the immunosuppressive mechanisms of cyclosporine A. Repetitive studies were excluded. Fifty accorded with the inclusive criteria, and 46 of them regarding tracheal transplantation were selected for the full-texts as the references.
LITERATURE EVALUATION： Forty-six included articles included 6 ones about the clinical use and effects of cyclosporine A, and 40 involving the related studies on the molecular mechanisms of cyclosporine A.
DATA SYNTHESIS： The review of literatures indicates that, the immunosuppressive mechanisms of cyclosporine A consist of： ①the calcineurin/nuclear factor of activated T-cells pathway,②the activation of JNK and P38 signaling pathways, ③other effects.
CONCLUSION： Cyclosporine A selectively regulates the function of peripheral blood lymphocytes subgroup, blocks the activation of cytotoxic T-cells, and possibly inhibits the formation or reaction of memory T-cells. But it doesn’t affect activation and proliferation of suppressive T-cells, or expression of interleukin-2 receptors, which may induce selective immunosuppression.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2008年第5期937-940,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
