摘要
卵黄抗体亦称卵黄免疫球蛋白(IgY),由母鸡血清中选择性地转移到卵黄,是卵黄中唯一的免疫球蛋白,为后代提供被动免疫保护。用鸡代替哺乳动物来生产多克隆抗体具有很多优点:鸡蛋易于收集,抗体产量高,提纯方法简单易行,且IgY不与类风湿因子结合,不激活哺乳动物补体因子等特性,使得IgY在制备针对多种抗原的多克隆抗体、免疫检测诊断、人类和动物疾病的预防治疗方面均得到了广泛的应用,在人类的免疫避孕方面也显示了良好的应用前景。
IgY antibodies, also called egg yolk immunoglobulins, are the only immunoglobulins in egg yolk and transferred in the female from serum to egg yolk to confer passive immunity to embryos and neonates. Using hens instead of mammals as the immunization host brings a number of advantages： Eggs are cheap and readily available; antibody levels in yolks are high; IgY isolation is fast and simple; and what is more; IgY neither binds the rheumatoid factor nor reacts to the mammalian complement factor. All these differences make IgY technology more widely applicable, such as in the production of polyclonal antibodies against various antigens, immunodiagnostics and immunotherapy, and many medical areas in both animals and human. IgY also has a good prospect in human immunocontraception. Natl J Androl, 2008.14（2） ：166-170
出处
《中华男科学杂志》
CAS
CSCD
2008年第2期166-170,共5页
National Journal of Andrology
关键词
卵黄抗体
卵黄免疫球蛋白
IGY
纯化
临床应用
yolk antibody
yolk immunoglobulin
IgY
purification
clinical application
