摘要
肝纤维化是慢性肝病共有的病理改变,其本质是以胶原为主的细胞外间质(extracellular matrix,ECM)合成增多,而降解相对减少,两者失去动态平衡,致使过多ECM沉积于肝内.近年来随着分子生物学技术的发展,肝纤维化的基因治疗成为可能.目前,常用的一般方法是将足够的治疗性基因导入受损的肝脏,使外源基因得到表达调控,达到延缓和治愈肝纤维化的目的.
Hepatic fibrosis is a common pathological process of chronic liver diseases, characterized by increased synthesis and relatively low degradation of extracellular matrix （ECM） resulting from their dynamic imbalance. Recent progress in molecular biology techniques has made it possible to treat hepatic fibrosis with gene therapy. At present, the commonly used method is to induce the expression of exogenous genes by transducing enough therapeutic genes into injured liver to delay or cure liver fibrosis.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第3期284-288,共5页
World Chinese Journal of Digestology
关键词
肝纤维化
基因
治疗
Hepatic fibrosis
Gene
Therapy
