摘要
本工作以钾离子透入法引起大鼠甩尾反应的电流强度为痛反应指标，测定动物痛阈，观察到大鼠中脑导水管周围灰质（ＰＡＧ）内注入神经降压素（ＮＴ）后，大鼠痛阈和电针镇痛效应明显升高；注入抗神经降压素血清后，痛阈和电针镇痛效应明显降低。注入纳洛酮后，可明显减弱ＮＴ镇痛和电针镇痛的效应。提示，ＰＡＧ内ＮＴ参与电针镇痛的病理生理过程。
The effect of periaqueductal gray (PAG) injection of neurotensin (NT), anti NT serum (ANTS), and naloxone (Nx) on both the pain threshold and electroacupuncture (EA) analgesia in rat was investigated in this study. The potassium iontophoresis induced tail flick was used to measure the pain threshold. NT administraiton induced an increase in pain threshold and enhanced EA analgesia. Injection of ANTS reduced the pain threshold significantly and diminished the effect of EA analgesia. Furthermore,pre injection of Nx into PAG could weaken analgesia effect of NT and NT EA analgesia. These results indicate that NT in PAG is involved in pain modulation and plays a role in EA analgesia. The effect of NT may be partly conducted by endogenous opiate peptides.
出处
《中国应用生理学杂志》
CAS
CSCD
1997年第3期253-256,共4页
Chinese Journal of Applied Physiology
关键词
电针镇痛
神经降压素
中脑
导水管周围灰质
neurotensin
anti neurotensin serum
naloxone
electroacupuncture analgesia
