摘要
目的观察低剂量吉西他滨24小时持续静脉滴注联合奥沙利铂、强的松（GPP方案）治疗复发性及难冶性非霍奇金淋巴瘤（NHL）的近期疗效。方法20例复发性及难治性NHL患者，应用GPP方案，即：Gem 120mg／m^2，24小时持续静脉滴注，d1.8，L—OHP 80mg／m^2，静脉滴注，d1.8；PDN60mg／m^2，口服，d1～5；21d为1周期，完成2周期以上者做疗效评价。结果20例患者中，CR6例，PR8例，NC3例，PD3例，总有效率（CR＋PR）为70％。结论GPP方案治疗复发性及难治性NHL的近期疗效满意，毒性反应可耐受。
Objective To evaluate the short-term efficacy of low-dose Gemcitabine 24 h continuous infusion plus Oxaliplatin and Prednisone （GPP） regimen in the treatment with relapsed or refractory non- Hodgkin＇s lymphoma（NHL）. Methods Twenty cases with relapsed or refractory NHL were treated with GPP regimens Gem 120 mg/m^2 , 24 h continuous infusion, d1.8 ;LOHP 80 mg/m^2 , ivgtt, dr,8 ;PDN 60 mg/ m^2 ,p. o,d1-5 ; Every 21 days is one cycle. Their clinical response was assessed after 2 cycles of chemotherapy. Results In the 20 cases, the complete response was 6 cases, the partial response was 8 cases, 3 cases was no change, 3 case was progressive, the overall response rate（CR ＋ PR） was 70 %. Conclusion GPP regimen can achieve a satisfied result in the treatment of relapsed or refractory NHL,and the toxicity was endurable.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2008年第2期121-123,共3页
Cancer Research on Prevention and Treatment
