摘要
Th细胞的极化受多种因素影响，CD4^＋T细胞可分化为不同的效应细胞亚群而发挥不同的免疫功能。Th1／Th2之间的平衡因直接影响免疫应答的类型，从而决定疾病的发展过程和感染结局。宿主在疟原虫抗原刺激下，抗原提呈细胞、CD4^＋CD25^＋调节性T细胞可通过与Th细胞等相互作用，影响T-bet、GATA3转录因子表达，进而改变Th细胞的分化方向。该文主要就疟疾感染中Th细胞功能变化及其调控机制作一综述。
Th cell polarization can be influenced by many factors, CD4^＋ T cell may transform into multiple T cell subgroups exhibiting different immune functions. The balance of Th1/Th2 has direct effect on the type of immune response as it determines the development and the outcome of infectious diseases. When a host is infected with Plasmodium, antigen presenting cell （APC） and CD4^＋ CD25^＋ regulatory T cell interact with Th cell, affecting the expression of T-bet and GATA3, and resulting in altered differentiation trend of Th cell. This article summarized the changes in Th cell function and regulative mechanism in malaria infection.
出处
《国际医学寄生虫病杂志》
CAS
2008年第1期14-17,共4页
International JOurnal of Medical Parasitic Diseases
关键词
疟疾
TH细胞
功能变化
调控机制
Malaria
Th cell
Change of function
Regulative mechanism
