摘要
目的评价莫西沙星与左氧氟沙星治疗泌尿道感染的疗效、不良反应及成本-效果。方法采用随机、开放、平行对照试验设计。选择泌尿道感染病例195例,其中可评价病例176例,莫西沙星组（治疗组）90例,给予莫西沙星400 mg,1次/d,疗程7-14 d;左氧氟沙星组（对照组）86例,给予左氧氟沙星200 mg,2次/d,疗程为10 d。结果莫西沙星组临床总有效率97.8%,左氧氟沙星组91.9%,两组的细菌清除率分别为96.7%和94.2%,不良反应发生率分别为7.78%和9.30%,两组比较差异均无统计学意义（P〉0.05）,成本效果比分别为2.67和0.51（P〈0.01）。结论左氧氟沙星的治疗方案为治疗泌尿道感染的较佳方案。
Objective To estimate the curative effect, adverse reaction and cost - effectiveness of moxifloxacin and levofloxacin for treatment of urinary tract infection. Methods The trial design was random, open, and parallel control. 195 patients with urinary tract infection were involved. 176 cases evaluated were randomly divided into the treatment group and the control group. 90 patients in treatment group were given 400 mg moxifloxacin capsule for 10 d, while 86 patients in control group were given 200 mg levofloxacin capsule twice a day for 7 - 14 d. Results The total clinical effective rate of case and control group were 97. 8% and 91.9% respectively, and the bacterial eliminating rate were 96.7% and 94.2% respectively, and the rate of adverse reaction were 7.78% and 9.30% respectively. There was no significant difference between two groups （ P 〉 0.05 ）. The cost - effectiveness ratio of moxifloxacin was 2.67 and 0.51 for levofloxacin （ P 〈 0.01 ） . Conclusion The therapeutic scheme of levofloxacin seems to be the best one for treating urinary tract infection .
出处
《临床医学》
CAS
2008年第2期42-43,共2页
Clinical Medicine
关键词
莫西沙星
左氧氟沙星
泌尿道感染
成本-效果分析
Moxiiloxacin
Levofloxacin
Urinary tract infection
The cost -effectiveness analysis
