摘要
目的测定急性脑梗死(ACI)患者血浆中促肾上腺皮质激素(ACTH)和皮质醇水平及其昼夜节律的变化,探讨ACTH和皮质醇对ACI患者的临床意义。方法采用放射免疫法检测34例病情程度不同的ACI患者和30例对照者在8:00、16:00和24:00时的血浆ACTH和皮质醇含量,分析24h内ACTH和皮质醇水平变化与神经功能缺损程度和预后的关系。结果ACI患者8:00、16:00和24:00时的血浆ACTH和皮质醇水平均高于对照组(P<0.05);血浆ACTH和皮质醇水平在3个时点的变化与神经功能缺损程度呈正相关;神经功能缺损程度重、预后差的患者两种激素水平明显增高,昼夜节律逆转。结论检测血浆ACTH和皮质醇水平,观察其昼夜节律变化,可判断ACI患者的病情和预后。
Objective The aim of this study was to detect the changes of plasma adrenocorticotropic hormone （ACTH） and cortisol at 3 different time points within 24 hours in patients with acute cerebral infarction and discuss their clinical significance. Methods The levels of plasma ACTH and cortisol were measured at 8： 00, 16. 00 and 24. 00 o＇clock by radioimmunoassay in 34 patients with cerebral infarction and 30 controls, and the degree of brain damage as well as clinical outcome was assessed. Results Plasma ACTH and cortisol levels were significantly increased in acute cerebral infarction. Both ACTH and cortisol levels at 3 different time points were correlated positively with the degree of brain damage. Their levels were significantly statistically higher in brain damage of serious degree with unfavorable prognosis than in damage of moderate and mild degree with favorable prognosis. Circadian rhythm of both ACTH and cortisol secretion was reversed in those patients with brain damage of serious degree and unfavorable prognosis. Conclusion High activations of ACTH and cortisol and their circadian rhythm reverses or disturbances may be used for the judgment of the severity and prognosis of acute cerebral infarction.
出处
《兰州大学学报（医学版）》
CAS
2008年第1期23-25,共3页
Journal of Lanzhou University（Medical Sciences）
关键词
促肾上腺皮质激素
皮质醇
急性脑梗死
adrenocorticotropic hormone
cortisol
acute cerebral infarction
