摘要
目的:探讨特异性免疫治疗对慢性荨麻疹患者外周血白三烯B4和前列腺素D2的影响。方法:采用ELISA法检测特异性免疫治疗前后患者LTB4和PGD2血清水平。结果:慢性荨麻疹患者外周血PGD2治疗前(17.8003±5.16899)pg/mL,治疗后(14.4144±5.88605)pg/mL和LTB4治疗前(14.0203±2.99936)pg/mL,治疗后(12.8760±3.72229)pg/mL,两者治疗前后均明显高于正常对照(P<0.05),经过特异性免疫治疗LTB4和PGD2水平明显下降(P<0.01,P<0.05)。结论:特异性免疫治疗可以通过降低PGD2和LTB4水平起作用。
Objective： To investigate the effect of specific immunotherapy on the serum levels of PGD2 and LTB4 in the patients with idiopathic chronic urticaria （ICU）, Methods： Serum levels of PGD2 and LTB4 before and after treatment were measured by ELISA, Results： The levels of PGD2 and LTB4 in the patients with ICU were significantly higher than those of control group （ P 〈 0.05）. After treatment, the level of LTB4 was significantly decreased than that of control subjects （ P 〈 0.05）. Before treatment, there was no significant difference in the level of PGD2 between the study group and the control group, but the difference was significant after the treatment. Condusion： The role of specific immunotherapy in the treatment of ICU is through decreasing the level of PGD2 and LTB4.
出处
《中国麻风皮肤病杂志》
2008年第3期179-180,共2页
China Journal of Leprosy and Skin Diseases
