期刊文献+

老年非小细胞肺癌化疗进展 被引量:1

Progresses of the Chemotherapy for the Elder Non-small Cell Lung Cancer
在线阅读 下载PDF
导出
摘要 非小细胞肺癌被认为是一个典型老年疾病,因老年人生理的特殊性,年龄〉70岁的患者往往被排斥在临床研究之外,缺乏多中心临床随机对照研究,目前尚无肯定的标准治疗。现通过相关文献资料分析老年人非小细胞肺癌化疗的必要性,介绍第3代抗肿瘤药物和不同化疗方案的疗效,以及分子靶向治疗药物(如吉非替尼)在老年人中的研究进展,为老年人肺癌化疗方案的选择提供参考。 Non-small cell lung cancer(NSCLC) is considered to be a typical diseases in the elder,. There is still no standardized therapy for it at present because it is lack of multicentral random control study in clinic and patients over 70 years old are always excluded from the clinical study because of their special physiology. This article not only analyzes the necessity of chemotherapy for elder person with NSCLC, but also introduces the efficacy of the antitumor drug in the third generation and different chemotherapeutic scheme,as well as study progresses of molecular targeted therapeutic drugs in the eider, such as gefitinib, in order to provide reference for the selection of chemotherapeutic scheme for elder NSCLC.
出处 《医学综述》 2008年第7期1012-1014,共3页 Medical Recapitulate
关键词 老年人 非小细胞肺癌 化疗 进展 Elder Non-small cell lung cancer Chemotherapy Progress
  • 相关文献

参考文献21

  • 1Curran MP,Plosker GL. Vinorelbine: a review of its use in eldly patients with advanced non-small cell lung cancer[J]. Drugs aging,2002,19 (9) :695-721.
  • 2Altavilla G, Adamo V, Buemi B,et al. Gemcitabine as single agent in the treatment of eldly patients with advanced non-small cell lung cancer[ J ]. Anticancer Res ,2000,20 (5C) :3675-3678.
  • 3Roszkowski K, Pluzanska A, Krzakowski M, et al. A multicenter, randomized,phase Ⅲ study of docetaxel plus best supportive care versus best supportive care in chemotherapy-naive patients with metastatic or non-resectable localized non-small cell lung cancer (NSCLC) [ J]. Lung Cancer,2000,27 ( 3 ) : 145-157.
  • 4Buechcfi G, Ferrigno D. Vinorelbine in elderly patients with inoperable non-small cell lung carcinoma :a phase Ⅱ study [ J ]. Cancer, 2000,88 ( 12 ) : 2677-2685.
  • 5Sorraritchingchai S, Thongprasert S, Charoentum C , et al, Treatment of advanced non-small cell lung cancer with vinorelbine in elderly Thai patients [ J ]. J Med Assoc Thai, 2004, 87 ( 4 ) : 367-371.
  • 6Gridelli C. The ELVIS trial: a phase Ⅲ study of single-agent vinorelbine as first-line treatment in elderly patients with advanced non-small cell lung cancer. Elderly Lung Cancer Vinorelbine Italian Study [ J ]. Oncologist, 2001,6 ( Suppl 1 ) :4 -7.
  • 7Kanard A,Jatoi A,Castillo R,et al. Oral vinorelbine for the treatment of metastatic non-small cell lung cancer in elderly patients : a phase Ⅱ trial of efficacy and toxicity [J]. Lung Cancer, 2004,43 (3) :345-353.
  • 8Martoni A, Di Fabio F, Guaraldi M, et al. Prospective phase Ⅱ study of single-agent gemcitabine in untreated elderly patients with stage Ⅲ B/Ⅳ non-small cell lung cancer[ J ]. AM J Clin Oncol, 2001,24(6) :614-617.
  • 9Massuti B,Carops C,Barcelo JR,et al. Weekly paclitaxel(PCT) in non-small cell lung cancer(NSCLC) :Results in older or flail patients. A Spanish Lung Cancer Group Trial( GECP 00-02 ) [ J]. J Clin Oncol,2004,22(14S) :740s.
  • 10Fidias P,Supko JG, Martins R , et al. A phase Ⅱ study of weekly paclitaxel in elderly patients with advanced non-small cell lung cancer[J]. Clin Cancer Res,2001,7(12) :3942-3949.

同被引文献28

引证文献1

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部