摘要
帕金森病是一种中老年人常见的中枢神经系统退行性疾病,其发病机制至今尚未明确,目前认为与遗传因素、环境因素、兴奋性毒性、线粒体功能障碍与氧化应激、免疫学异常、年龄老化、细胞凋亡、泛素蛋白酶体系统功能障碍、多聚ADP核糖聚合酶过度活化等因素密切相关。文章在上述几个方面针对帕金森病的发病机制研究进展进行综述。
Parkinsen＇s disease （PD） is a common neurodegenerat ive disease in the central nervous system of the middle and old aged peoples, of which the pathogenesis remains unclear to this day. It is presumed that PD is cor related with genetic factor, environmental factor, toxicity of excitability, mitoch ondrial functional disturbance and oxidative stress, dysfunotion of immunology, ageing, apoptosis, functional disturbance of ubiquitin-proteasome system, excess activation of [ poly ] ADP-fibose polymerase, and so on. This article reviews progresses of PD about its pathogenesis in these aspect.
出处
《医学综述》
2008年第7期1040-1042,共3页
Medical Recapitulate
关键词
帕金森病
病因学
遗传学
环境
Parkinson＇s disease
Etiology
Genetics
Environment
