摘要
目的探讨染色法乳腺癌前哨淋巴结(SLN)活检的影响因素。方法采用亚甲蓝染色法对83例乳腺癌行腋窝蓝染淋巴结活检,后行常规腋窝淋巴结清扫(ALND),两标本均送病理检查。比较患者年龄、肿瘤大小、肿瘤位置、术前化疗、术前或术中活检及腋窝淋巴结肿大等因素对SLNB检出率、准确率和假阴性率的影响。结果全组83例患者SLN的检出率为91.56%(76/83);准确率为94.73%(72/76);灵敏度为84.61%(22/26);假阴性率为15.38%(4/26)。经统计学处理显示:患者年龄、肿瘤位置、术前是否化疗与SLN的检出率无明显相关(P>0.05),肿瘤大小(>5cm)、术前或术中活检、腋窝淋巴结状态与SLN的检出率差异有显著性(P<0.05)。腋窝淋巴结肿大对SLNB的准确率差异有显著性(P<0.05);各种因素对SLNB的假阴性率均无明显相关(P>0.05)。结论前哨淋巴结活检能准确预测乳腺癌腋窝淋巴结的状态,亚甲蓝染色法可以成功确定SLN。
[objective] To study the influencing factor by stained technique of sentinel lymph node （SLN） biopsy for breast cancer. [Methods] Eighty three female breast cancer patients were injected with vital blue to find the sentinel lymph nodes during operation. All patients were treated by the radical axillary lymph nodes dissection （ALND）. This kind of two dissected specimens was submitted to pathological examination. The influence to sentinel lymph node biopsy＇s finding out rate, accuracy rate, sensitivity and the false negative rate by comparing with the factors which are the age of patient, the size and position of the tumors, the biopsy before or during operation, and the intumescences of SLN et al. [Results] The finding out rate, accuracy rate, sensitivity and the false negative rate was respectively 91.56%（76/83）,94.73%（72/76）, 84.61%（22/26） and 15.38%（4/26） in the group of eighty three patients. It was disposed by statistics and revealed that there is ho obvious correlation about the age of the patient, the position of the tumors and weather having chemistry treatment before operation to the SLN＇s finding out rate （P〉 0.05）, but there is obvious influence through the size of tumors（〉5 cm）, the biopsy before or during operation, the fettle of tumors to the SLN＇s finding out rate （P〈0.05）. The intumescences of SLN has obvious influence to SLNB＇s accuracy rate （P〈0.05）; and all kinds of factors have no influence to SLNB＇s false negative rate. [Conclusion] Sentinel lymph node biopsy （SLNB） could be accurately predicted the axillary node status for breast cancer;, the vital blue technique could be successfully identified sentinel lymph node （SLN）.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2008年第6期785-788,共4页
China Journal of Modern Medicine
