摘要
目的分析青年乳腺癌的临床和病理特点及其与预后的关系。方法回顾性分析86例〈35岁乳腺癌的临床资料。观察患者的长期生存率，分析其临床特点及影响预后的因素。结果全组〈35岁乳腺癌占同期收治乳腺癌的7．90%。总的5年和10年生存率分别为63．5％和46．3％，肿瘤〈2cm、2—5cm、〉5cm患者的10年生存率分别为84．5％、53．8％和25．6％（P〈0．05）；腋淋巴结转移阴性，1-3枚阳性，和≥4枚阳性患者10年生存率分别为79．7％、43．9％和32．4％（P〈0．05）；用三苯氧胺（TAM）治疗和未用TAM治疗的患者，10年生存率分别为64．5％和43．7％（P〈0．05）；妊娠哺乳期乳腺癌占本组患者的13．95％，其10年生存率与非妊娠哺乳期乳腺癌相比，差异无统计学意义。结论本组青年乳腺癌患者，影响其预后的主要因素为肿瘤大小、腋淋巴结转移和受体状况，进行正规的综合治疗可能改善生存期。
Objective To analyze the clinical characteristics,survival and prognosis of breast cancer patients under 35 years of age. Methods 86 breast cancer patients under 35 years treated from Mar 1990 to Jan 2003 were retrospectively reviewed. Clinical features, survival and prognostic factors were analyzed by SPSS10.0 statistic software. Results Breast cancer patients under 35 years accounted for 7.9% of all breast cancers in our hospital .The overall 5-and 10-year survival rates were 63.5% and 46.3% .respectively. For patients with tumor 〈2cm,2 - 5cm or 〉 5cm,the 10-year survival rates were 84.5% ,53.8% or 25.6% （P 〈 0.05） .For those with number of positive axillary lymph nodes 0,1 - 3, or ≥ 4, the lO-year survival rates were 79.7 %, 43.9 % or 32.4 % （ P 〈 0.05 ）. For patients who had been treated with or without tamoxifen, the 10-gear survival rates were 64.5 % and 43.7 % （ P 〈 0.05 ）. For those complicated with pregnancy and lactation which was found in 13.95% of such patients,the 10-year survival rate was 43.7% .In the multivariate analysis,independent prognostic factors that might improve the overall survival were tumor size, axillary metastatic status and tamoxifen treatment. Conclusion Tumor size, metastasis of axillary lymph nodes, ER and PR were important prognostic factors in young breast cancer patients, combined therapy may improve the survival time.
出处
《四川医学》
CAS
2008年第4期399-401,共3页
Sichuan Medical Journal
关键词
青年女性
乳腺癌
生存率
预后
younger women
breast cancer
survival rate
prognosis
