摘要
目的比较齐拉西酮与利培酮治疗精神分裂症的疗效、安全性及对认知功能的影响。方法将63例精神分裂症患者随机分为齐拉西酮组(31例)和利培酮组(32例)。疗程为6周。采用阳性和阴性症状量表(PAN-SS)、临床疗效总评量表(CGI-CI)、韦氏记忆量表(WMS-RC)、不良反应量表(TESS)进行评定。结果治疗6周后,齐拉西酮显效率为61.3%,总有效率87.1%,而利培酮组则分别为65.6%和90.6%,两组疗效无显著性差异。两组治疗后WMS-RC的短时记忆、瞬时记忆和记忆商数均明显高于治疗前,但两组间比较无显著性差异,两组不良反应的发生率亦无明显差异,且程度均较轻。结论齐拉西酮与利培酮治疗精神分裂症的疗效相当,依从性好,均能明显改善患者的认知功能。
Objective To compare the clinical efficaey safety and the effect on eongnitive function of ziprasidone and lisper done in the treatment of schizophrenia. Methods Sixty - three patients with schizophrenia were randomly assigned to two groups, study group treated with ziprasidone （ n = 31 ） and control group with risperdone （ n = 32） for 6 weeks. The positive and negative symptoms scale（PANSS） ,Wechsler memery scale（ WMS - RC） and TESS were used to evalute the effects and side effects before and after the treatment. Results After 6 weeks treatment the marked improvement rate was 61.3% and effective rate was 87. 1% in ziprasidone group,while 65.6% and 90. 6% in risperdone group,and there were no significant differences between two groups. The short - memory ,immediate memory and memory quotients of WMS - RC increased significantly after treatment in both groups and no difference in WMS - RS was found between them. The incidence of adver effects in two groups had no significant difference and the side effects of both groups were hss. Conclusion Ziprasidone is as effective as risperidone for the treatment of schizophrenia and has good compliance. It can improve the cognitive function in schizophrenia patients.
出处
《四川精神卫生》
2008年第2期94-96,共3页
Sichuan Mental Health
