摘要
目的探讨苯环喹溴铵对大鼠变应性鼻炎的治疗作用及机制。方法以卵清白蛋白(Ova)和Al (OH)_3建立大鼠变应性鼻炎模型。将60只大鼠随机分为模型组,苯环喹溴铵大、中、小剂量组,倍氯米松组和溶媒对照组,每组10只大鼠。各组动物经鼻给予相应药物2 wk后,观察各动物的症状和鼻黏膜组织形态学的状况,对各动物单侧鼻分泌物进行称重,并检测血清和鼻黏膜中Ova特异性IgE。结果模型组大鼠症状评分、鼻分泌物重量、血清和鼻分泌物中Ova特异性IgE水平及鼻黏膜病理学评分均高于溶媒对照组(P<0.01)。与模型组相比,苯环喹溴铵各剂量组大鼠的鼻炎症状均得到明显改善(P<0.01);大、中剂量组大鼠鼻黏膜的组织形态改变明显减轻(P<0.01);大剂量组大鼠血清和鼻黏膜中的Ova特异性IgE水平以及鼻分泌物量均明显降低(P<0.01)。结论经鼻给予苯环喹溴铵,对于大鼠变应性鼻炎有明显的治疗作用,其作用机制之一可能是通过降低Ova特异性IgE来实现的。
AIM To investigate the curative effects and its mechanism of bencycloquidium on the allergic rhinitis （AR） in rats. METHODS The rat model of allergic rhinitis were induced by ovalbumin （Ova） and Al（OH）3. Sixty rats were randomly devided into model group, bencycloquidium high medium and low doses groups, beclomethasone group, and vehicle group （each group including 10 rats）. After 2 weeks of intranasal administration, the symptoms and morphological features of nasal mucosa of each rat were observed, unilateral nasal secretion of each rat was weighed, and Ova-specific IgE in serum and nasal seretion of each rat were assayed. RESULTS Compared with the vehicle group, the nasal symptoms scale, nasal secretion weight, Ova- specific IgE levels in serum and nasal mucosa, and morphological changes scale of nasal mucosa of rats in the model group were all higher. Compared with the model group, the nasal symptoms of rats in each of the bencycloquidium treament groups showed remarkably relieved （P 〈 0.01 ） , morphological changes of nasal mucosa in high and medium doses of bencycloquidium treatment groups ap （P 〈 0.01 ） , Ova-pecific IgE in serum and nasal mucosa and nasal bencycloquidium treatment group revealed obviously decreased （P 〈 0.01 ）. peared to be significantly alleviated secretion of rats in high dose of CONCLUSION Bencycloquidium administered intranasally is effective in treating AR, and the mechanism might be through decreasing the Ova- specific IgE.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2008年第3期191-194,共4页
Chinese Journal of New Drugs and Clinical Remedies
基金
2006年度科技型中小企业技术创新基金项目(06C26211100623)
关键词
鼻炎
变应性
常年性
动物
实验
大鼠
苯环喹溴铵
rhinitis, allergic, perennial
animal, laboratory
rats
bencycloquidium
