摘要
目的探讨老年(≥75岁)急性心肌梗死患者静脉溶栓的疗效及安全性。方法将62例老年急性心肌梗死患者随机分为溶栓组和常规治疗组;溶栓组32例,采用尿激酶静脉溶栓加皮下注射小剂量低分子肝素钙。常规治疗组30例,除不用尿激酶及小剂量低分子肝素钙外,其余治疗均与溶栓组相同。结果冠状动脉再通率溶栓组为65.6%(21/32),常规治疗组为16.7%(5/30),两组比较差异具有显著性(P<0.05);溶栓组病死率6.3%(2/32),而常规治疗组病死率为23.3%(7/30),两组比较具有显著差异性(P<0.05);两组无严重出血并发症,出血并发症比较差异无显著性(P>0.05)。结论尿激酶静脉溶栓治疗老年急性心肌梗死可以提高冠状动脉再通率,降低死亡率和改善预后,是可行性治疗措施。
Objective To investigate the intravenous thrombolytic efficacy and safety in senile patients （≥ 75 years of age） with acute myocardial infarction. Methods sixty-two senilez patients with acute myocardial infarction were randomly divided into thrombolytic group and the conventional treatment group;in thrombolytic group 32 patients gave intravenous thrombolytic treatment with urokinase and low-dose subcutaneous injection of low-molecular-weight heparin calcium other 30 cases in the conventional therapy group only routine treatment, The curative and untoward effects in the two groups were observed and compared. Results Coronary artery recanalization in thrombolytic group was 65.6% （21/32）, only 16.7%（2/32） in the conventional treatment group,and the difference between the two groups was significant （P 〈0.05）, The mortality in thrombolytic group was 6.3% （2 / 32）, while the conventional therapy group reached 23.3% （7 / 30）（P 〈0.05）, but there was no serious bleeding complications in the two groups （P〉 0.05）. Conclusion Intravenous thrombolytic therapy for senile patients with acute myocardial infarction can improve coronary artery recanalization, lower mortality and make the prognosis more better.
出处
《实用心脑肺血管病杂志》
2008年第2期96-98,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
静脉溶栓疗法
老年心肌梗死
尿激酶
Intravenous thrombolytic therapy Myocardial infarction Senile patient
