摘要
目的探讨阿得福韦酯治疗慢性乙型肝炎对患者血清纤维化指标的影响。方法对60例慢性乙型肝炎患者阿得福韦酯治疗前和治疗1年后血清透明质酸(HA)、层粘蛋白(LN)Ⅲ前胶原(PcⅢ)和Ⅳ型胶原(Ⅳc)测定水平进行检测。结果治疗组血清肝纤维化指标有明显下降(P<0.01),与对照组比较差异有统计学意义(P<0.01)。结论慢性乙型肝炎经阿得福韦酯治疗1年后肝纤维化指标有明显降低。
Objective To investigate the affection of Adefovir dipivoxil on the serum fibrosis marks in patients with chronic hepatitis B. Methods 120 patients with chronic hepatitis B were randomly divided into treatment group and control group. The treatment group （ n = 60 ） was treated with Adefovir dipivoxil. The levels of serum hyaluronic acid （ HA ）, laminin （ LN ）, type Ⅲ procollagen （ Pc Ⅲ ）, type Ⅳ collagen （ Ⅳ c ） of each group were detected before treatment and after 1 year of treatment. Results The level of serum HA, IN, pC Ⅲ and Ivc significantly decreased after the treatment of Adefovir dipivoxil （P 〈 0.01 ）. The level of each indexes of the treatment groups was obviously different from that of the control group after the treatment （ P 〈 0.01 ）. Conclusions Adefovir dipivoxil could obviously decreasethe serum hepatic fibrosis index in patients with chromic hepatitis B.
出处
《实用全科医学》
2008年第5期489-490,共2页
Applied Journal Of General Practice
关键词
慢性乙型肝炎
阿得福韦酯
肝纤维化
Chronic hepatitis B
Adefovir dipivoxil
Hepatic fibrosis
