摘要
目的:研究子痫前期患者外周血单核细胞共刺激分子B7-1和B7-2的表达水平,探讨B7-1、B7-2在发病中的作用。方法:收集20例重度子痫前期患者、20例轻度子痫前期患者、20例妊娠期高血压患者、20例正常妊娠妇女、20例正常未孕妇女的外周血单核细胞,用流式细胞技术检测B7-1、B7-2的表达率。结果:①正常妊娠时B7-2(27.04±9.88)表达水平升高,B7-1(6.00±1.84)表达处于低水平(P<0.01);②重度子痫前期组B7-1表达率和轻度子痫前期组B7-1表达率均显著高于其他各组(P<0.01)。结论:子痫前期患者外周血单核细胞共刺激分子B7-1、B7-2异常表达在其发病中具有重要作用,可能是子痫前期发生的重要原因。
Objective： To evaluate the expression level of costimulatory molecule B7 - 1 and B7 -2 in peripheral from patients with hypertensive disorder complicating pregnancy and to investigate the function of B7 - 1 and B7 - 2 in the pathogenesis. Methods： Peripheral blood were sampled from 20 patients with severe pre - eclampsia （PE） and 20 patients with mild PE and 20 patients with gestational hypertension and 20 healthy pregnant women and 20 non - pregnant women. B7 - 1 and B7 - 2 in peripheral blood were determined by flow cytometric technique. Results： The percentage of B7 - 2 positive ceils in peripheral blood mononuclear in healthy pregnant women was higher than that in other groups, and B7 - 1 was lower than that in PE and gestational hypertension （P 〈 0. 01 ） . The percentage of B7 - 1 positive cells in peripheral blood mononuclear in patients with severe （ 10.67 ± 2. 57） and mild （ 10. 14 ± 2. 31 ） preeclampsia were higher than that in other groups （P 〈 0. 05 ） . Conclusion： Hypertensive disorder complicating pregnancy is a syndrome of abnormal of B7 - 1 and B7 - 2 as compared with healthy pregnany. It might be the mason of hypertensive disorder complicating pregnancy.
出处
《中国妇幼保健》
CAS
北大核心
2008年第13期1852-1854,共3页
Maternal and Child Health Care of China
基金
河北医科大学基金资助项目(项目编号:040306)
