摘要
目的探讨原发性高血压合并缺血性脑卒中与非对称性二甲基精氨酸(ADMA)及高敏C反应蛋白(hsCRP)的关系。方法选择134例原发性高血压患者(其中65例合并缺血性脑卒中,69例无脑卒中)及73例健康人,采用高效液相色谱法及酶联免疫分析法分别测定血清ADMA,hsCRP浓度,分析两者与原发性高血压合并缺血性脑卒中的关系。结果原发性高血压合并缺血性脑卒中患者血清ADMA,hsCRP浓度显著高于无脑卒中患者,差异有显著性(P<0.05);原发性高血压患者无论有无合并缺血性脑卒中,其血清ADMA,hsCRP浓度均高于健康对照组,差异有显著性(P<0.05)。结论原发性高血压合并缺血性脑卒中与血清ADMA及hsCRP具有一定相关性,血清ADMA,hsCRP浓度升高可能提示原发性高血压患者发生缺血性脑卒中的危险性增加。
Objective To study whether the level of serum asymmetric dimethylarginine and hsCRP is associated with increased risk for essential hypertension with ischemic stroke. Methods Serum level of ADMA and hsCRP was measured in 65 patients with essential hypertension and ischemic stroke, 69 patients with essential hypertension and 73 healthy people. Results Serum ADMA and hsCRP levels were significantly higher among patients with essential hypertension and stroke （P 〈 0.05 ）, Essential hypertension patients, with or without stroke had higher level of serum ADMA and hsCRP compared with the healthy people （P 〈 0.05）, Conclusion The level of serum asymmetric dimethylarginine and hsCRP is associated with increased risk for essential hypertension with stroke. The hypertension patients, with higher serum ADMA and hsCRP, may have more chances to have stroke.
出处
《广东医学》
CAS
CSCD
北大核心
2008年第5期769-771,共3页
Guangdong Medical Journal
基金
广州市科技计划项目(编号:2007J1-C0221)
