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妊娠期肝内胆汁淤积症中FXR调节胆汁酸代谢的分子机制研究进展

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摘要 妊娠期肝内胆汁淤积症(ICP)病因及发病机制目前仍不清楚,近年来关于其分子机制方面的研究取得了较大的进展,确认了多种胆汁酸转运蛋白及其基因,并发现其中大部分为"胆汁酸感受器"——法尼醇受体(FXR)的靶基因,胆汁酸作用于FXR,通过上调或下调靶基因的转录水平降低胆汁酸,形成胆汁酸的自身反馈调节机制,保护肝细胞免受毒性胆汁酸成分的损伤。
作者 邹姝丽 刘建
机构地区 重庆医科大学附属第二医院妇产科
出处 《国际检验医学杂志》 CAS 2008年第4期355-357,共3页 International Journal of Laboratory Medicine
关键词 胆汁淤积 肝内 孕妇 胆汁酸类和盐类 代谢 分子作用机制
分类号 R714.2 [医药卫生—妇产科学]
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参考文献17

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共引文献30

国际检验医学杂志
2008年 第4期

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