摘要
目的确定大豆异黄酮(soybean isoflavone,SI)改善由于雌激素缺失导致的围绝经期症状的生理效应有效剂量,并探讨其可能机制。方法90例45～60岁的绝经早期妇女,随机单盲分为SI84、126mg/(kgbw·d)两个剂量组和安慰剂对照组,每组30人接受追踪观察24w,每4w要求对象记录1w的潮热、出汗次数,做1次围绝经期症状评分(Kuppermanuscore),并在试验前、12w和24w时测定血清雌二醇(E2)、促卵泡生成素(FSH)和黄体生成素(LH)的浓度。结果在试验期间低、高剂量两组的潮热次数(%)分别为57.8±37.4和56.7±26.7和症状评分的下降率(%)分别为44.3±19.1和48.5±27.2,两组间无显著差异,而安慰剂组的潮热次数和症状评分下降率仅为(34.6±46.2)%和(27.8±15.5)%,显著低于前两组。血清E2、FSH和LH在试验各期各组间没有显著差异。结论大豆异黄酮84mg/d可以改善各种围绝经期症状,尤其是潮热、出汗症状,此效应与激素的调节关系不明显。
Objective To study the effect of soy isoflavones （SI） on menopausal symptoms, and its mechanism. Methods Ninety early postmenopausal women were randomly assigned to three treatment groups with daily dosages of 0 （placebo）, 84, 126 mg/ （kg bw · d） SI （n=30）. Hot flash frequency and Kuppermann score and serum 1713-estrodiol （Ez）, follicle-stimulating hormone （FSH） and luteinizing hormone （LH） were assessed at baseline, 12 w and 24 w posttreatment. Results The percent decreases of Kuppermann scores and hot flashes frequency of the two SI treatment groups were 57.8%±37.4%and 44.3%±19.1% in low dose group and （56.7±26.7）% and （48.5±27.2）% in high dose group respectively, significantly higher than those of the placebo group （34.6±46.2）% and （27.8±15.5） %. No significant difference was observed between the two SI groups. The contents of E2, FSH and LH among all groups were insignificantly different. Conclusion A daily dosage of 84 mg soy isoflavones or above could improve menopausal symptoms especially reducing hot flashes frequency and the mechanism seems not associated with serum E2, FSH, and LH.
出处
《营养学报》
CAS
CSCD
北大核心
2008年第2期203-207,210,共6页
Acta Nutrimenta Sinica
基金
广州市科技局立项课题(No.2002J1-C0081)
