摘要
目的探讨慢性心力衰竭合并贫血的临床特点及其预后。方法168例慢性心力衰竭患者,按血红蛋白(Hb)水平(男性Hb<120 g/L、女性Hb<110 g/L诊断为贫血)分为贫血组和非贫血组,比较两组患者的临床特点及心功能情况。此外,比较轻度与严重心力衰竭组的贫血发生率、贫血与慢性心力衰竭的严重程度和病死率的关系。结果冠状动脉性心脏病和高血压病是慢性心力衰竭的主要病因,分别占心力衰竭患者的51.8%和26.2%。总贫血发生率为18.5%,其中严重心力衰竭组为32.4%,显著高于轻度心力衰竭组的8.2% (P<0.05)。随访24个月,轻度心力衰竭组的病死率为5.2%,显著低于严重心力衰竭组的15.5%(P<0.05)。贫血组的病死率为25.8%,显著高于非贫血组的5.8%(P<0.01)。贫血组的血清肌酐水平为(123.41±52.22)μmol/L,显著高于非贫血组的(91.67±29.13)/μmol/L(P<0.05)。结论冠状动脉性心脏病和高血压病是慢性心力衰竭的主要病因,慢性心力衰竭患者常合并贫血,贫血程度与心力衰竭的严重程度有关,合并贫血的心力衰竭患者的病死率升高。
Objective To investigate the clinical features of patients with congestive heart failure （CHF） complicated with anemia and their prognoses. Methods A total of 168 patients with CHF were divided into anemia group （male Hb〈120 g/L, female 〈110 g/L） and non-anemia group according to their hemoglobin levels. The clinical features and cardiac functions were compared between the 2 groups. Based on clinical, cardiac ultrasound, and hematological examination, we compared the incidences of anemia between slight and severe heart failure groups and assessed the relationship between the severity of CHF and mortality patients in the 2 groups. Results Coronary heart disease and hypertension were the main causes of CHF, with their incidence being 51.8% and 26.2%, respectively in CHF patients. Of the 168 patients, 31 had anemia（18.5 %）. The incidence was significantly higher in patients with severe heart failure （32.4%）than those with slight heart failure （8.2%）（P〈0.05）. Five （5.2%） patients died in NYHA- I and Ⅱ and 11（15.5%） died in NYHA-Ⅲ and Ⅳ（P〈0.05） during 24 months follow-up. Mortality was significantly higher in anemic subjects （25.8%） compared with that in non-anemic subjects （5. 8%, P〈0.01）. Serum creatinine .was significantly higher in anemia group than innon anemia group（[123.41±52.22]μmol/L vs [91.67±29. 13]μmol/L, P〈0.05）. Conclusion Coronary heart disease and hypertension are the main causes of CHF. The patients with chronic heart failure often suffer from anemia; the degree of anemia is associated with the severity of heart failure. CHF patients complicated with anemia have higher mortality.
出处
《上海医学》
CAS
CSCD
北大核心
2008年第4期267-269,共3页
Shanghai Medical Journal
关键词
慢性心力衰竭
贫血
预后
Chronic heart failure
Anemia
Prognosis
