摘要
目的探讨进展性脑卒中与颈动脉斑块性质及血清高敏C反应蛋白(hs-CRP)水平之间的关系。方法急性前循环脑梗死患者210例,根据临床表现分为进展性脑卒中组(进展组,56例)和非进展性脑卒中组(非进展组,154例),健康体检者40例作为对照组。根据颈动脉超声检查又将脑梗死患者分为无斑块、稳定斑块和不稳定斑块进行比较。应用散射比浊法测定血清hs-CRP浓度。结果进展组颈动脉斑块发生率与非进展组差异无统计学意义。进展组颈动脉斑块以不稳定斑块(48.2%)为主,且颈动脉溃疡斑块的发生率高于非进展组(P<0.05)。进展组、非进展组、对照组血清hs-CRP分别为(10.47±5.26)mg/L、(7.23±4.34)mg/L、(1.79±1.08)mg/L,各组间差异有统计学意义(P<0.05)。脑梗死患者不稳定斑块、稳定斑块、无斑块间hs-CRP含量差异均有统计学意义(P<0.05)。结论颈动脉斑块不稳定性和hs-CRP水平的升高与进展性脑卒中的发生密切相关。
Objective To explore the role of plaque stability and C-reactive protein in the pathogenesis of progressive ischemic stroke. Methods 210 patients with acute anterior circulation cerebral infarction and 40 normal controls were investigated. The patients were divided into progressive ischemic stroke （PIS）group and non-progressive ischemic stroke （NPIS） group based on clinical manifestation. According to carotid ultrasonography, the patients were divided into no plaque group, stable plaque group and instable plaque group. Serum level of hs-CRP was measured by German BN ProSpec system,and the serum CRP levels in different groups were compared. Results There was no statistically significant difference between PIS group and NPIS group in carotid plaque incidence. Instable plaque was the main type of plaque in PIS group, and the incidence of ulcerative plaque was higher in PIS group than in the NPIS group. There were significant differ- ences in the levels of hs-CRP among PIS group [（10.47±5.26） mg/L],NPIS group [（7. 23± 4. 34） mg/L] and normal control group [（1.79±1.08） mg/L]. Level of hs-CRP was significantly different in instable plaque group （11.38±5.73） mg/L,stable plaque group （6.72±4.19） mg/L and no plaque group （4.13±2.27） mg/L. Conclusions Instable carotid plaque and increased hsCRP level may be closely related to ischemic stroke in progression.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2008年第5期358-360,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
关键词
脑血管意外
颈动脉疾病
C反应蛋白
动脉硬化
cerebrovascular accident
carotid artery diseases
C-reactive protein
arteriosclerosis
