摘要
目的探讨幼年强直性脊柱炎(JAS)患儿HLA-B27、T细胞亚群、免疫球蛋白和C反应蛋白(CRP)检测的临床意义。方法应用流式细胞术对32例JAS患儿(JAS组)和32名健康体检儿童(对照组)进行HLA-B27、外周血T淋巴细胞亚群(CD3+、CD4+、CD8+)检测,采用速率散射比浊法检测免疫球蛋白、CRP。结果JAS组患儿HLA-B27抗原阳性率为96.88%;JAS组患儿T细胞亚群CD3+、CD8+与对照组比较明显降低(均P<0.05),CD4+与对照组比较明显升高(P<0.05);JAS组患儿免疫球蛋白和CRP与对照组比较明显升高(均P<0.05)。结论JAS患儿存在炎症反应和免疫功能的亢进与紊乱,HLA-B27抗原在JAS发病中起了重要作用。
Objective To investigate the clinical value of measuring various immune indicators in children with juvenile ankylosing spondylitis （JAS）. Methods HLA-B27, peripheral T-lymphocyte subsets （CD^3＋,CD^4＋,CD^8＋） were detected with flow cytometer, immunoglobulin, C-reacting protein （CRP） were detected with rate nephelometry in 32 children with JAS （JAS group） and 32 normal children （control group）. Results The HLA-B27 antigen positive rate in JAS group was 96.88%, the levels of CD^3＋ and CD^8＋ in the JAS group were lower than those in control group, while CD^4＋, Immunoglobulin, CRP were higher than those in control group （P〈0.05, respectively）. Conclusion Children with JAS may have an inflammation and immunological aberrance.
出处
《浙江医学》
CAS
2008年第4期311-313,共3页
Zhejiang Medical Journal
