摘要
热休克蛋白70(HSP70)是一种有高度保守性的应激蛋白,在抗缺血-再灌注损伤中发挥重要作用。近年来越来越多的心脏、肝脏、肾脏等器官移植,以及心脑血管重建技术的开展,缺血-再灌注损伤都是一个不可忽视的环节,调动内源性的[A2]保护机制减轻损伤,成为目前一种新的途径之一[A3]。现就HSP70分别在脑、心、肝、肾、肺及小肠缺血-再灌注损伤中的作用作一综述。
Heat shock protein 70 （ HSP70 ） is a highly conservative nature of the stress protein ,which plays an important role in ischemia-reperfusion injury. Recent years have seen increasing numbers of organ transplantations （ e. g. heart, liver and kidneys ） and vascular remodelling was carried out. The ischemia-reperfusion injury is an overlooked part of the management of these procedures. It is a new method of arousing endogenous mechanisms of protection to reduce damage. This article is a review of the effect of HSP70 in ischemia-reperfusion injury in places such as the brain, heart, liver, kidneys, lungs and intestines.
出处
《心血管病学进展》
CAS
2008年第3期484-486,共3页
Advances in Cardiovascular Diseases
关键词
热休克蛋白70
缺血-再灌注损伤
器官移植
血管重建
heat shock protein 70
ischemia-reperfusion injury
organ transplantation
vascular remodeling
